Hepatocyte-specific deletion of Pparα promotes NAFLD in the
2020年4月16日 · We provide evidence that Pparα deletion in hepatocytes promotes NAFLD and liver inflammation in mice fed a HFD. This enhanced NAFLD susceptibility occurs without …
High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis …
The present study suggests for the first time that increased PPAR-γ expression by HFD is responsible for cardiac dysfunction via upregulation of mitochondrial enzymes HMGCS2, …
High-fat diet-activated fatty acid oxidation mediates intestinal ...
Here we find that, in loss-of-function in vivo models, PPARα and PPARδ contribute to the HFD response in ISCs. Mechanistically, both PPARs do so by robustly inducing a downstream fatty …
PPARγ signaling and metabolism: the good, the bad and the future
2013年5月7日 · HFD, ligands or TZDs (1) activate PPARγ-RXR functional heterodimers (2) and maintain metabolic homeostasis through direct regulation of genes harboring PPAR response …
LncRNA Gm35585 transcriptionally activates the peroxidase …
2 天之前 · In this study, we found that, among the PPAR-related differential expression genes after the treatment of Gm35585 under HFD condition, the change in EHHADH was consistent …
High-fat diet-activated fatty acid oxidation mediates ... - PubMed
2021年6月8日 · In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, …
Hepatocyte-specific deletion of Pparα promotes NAFLD in the
2020年4月16日 · We provide evidence that Pparα deletion in hepatocytes promotes NAFLD and liver inflammation in mice fed a HFD. This enhanced NAFLD susceptibility occurs without …
高脂饮食通过干预PPAR-γ上调脂肪酸的氧化和生 ... - X-MOL
2018年1月1日 · 本研究旨在确定在高脂血症患者中过剩游离脂肪酸（FA）对过氧化物酶体增殖物激活受体-γ（PPAR-γ）的激活是否对粮农组织和控制脂肪毒性和心脏凋亡的生酮酶具有正反 …
Cell子刊：高脂饮食或可导致肠道肿瘤 - 专区 - 生物谷
2021年6月24日 · 肠道对 hfd 的适应可能涉及 ppar 靶标的多个下游作用。 例如， PPARd 通过调节脂质吸收、胆固醇运输和肠内分泌细胞功能，在肠道生理中发挥关键作用。
High-fat diet activates a PPAR-δ program to enhance intestinal …
2021年4月1日 · We found that active PPAR-δ boosts ISC frequency and organoid formation and drives upregulation of PPAR-δ signature genes in intestinal crypts and ISCs, highlighting the …