
Isoform-specific functions of PPARγ in gene regulation and
2022年3月1日 · There are two main PPARγ isoforms, but the specific functions of each are not established. Here we generated mouse lines in which endogenous PPARγ1 and PPARγ2 …
PPAR gamma2: The main isoform of PPARγ that positively …
2022年8月1日 · Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-1 gene independently of PPAR …
Peroxisome Proliferator-Activated Receptors (PPARs) and …
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. Originally described as “orphan nuclear receptors”, they can bind both natural and …
Localization of PPAR isotypes in the adult mouse and human …
2016年6月10日 · There are three known PPAR isotypes (PPARα, PPARβ/δ and PPARγ) that have been identified in various species and are structurally homologous 4. Different PPAR …
Peroxisome proliferator-activated receptor isoform expression changes ...
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that are involved in lipid metabolism, differentiation, proliferation, cell death, and inflammation. Three …
PPARs: regulators of metabolism and as therapeutic targets in ...
PPARs are ligand-activated transcription factors that form a subfamily of the nuclear receptor superfamily. This PPAR subfamily consists of three isotypes: PPAR-α (NR1C1), PPARβ/δ …
PPAR
2012年8月9日 · We show, using in vitro analysis, lipidomics and in vivo animal models that PPAR γ isoforms control overlapping and distinct metabolic programs in prostate epithelia that lead to …
The PPARgene database - Home
Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptor / ligand-activated transcription factors superfamily. PPAR subfamily consists of 3 subtypes: PPAR-α, …
Peroxisome proliferator-activated receptors: role of isoform …
Here, we review the role of PPAR gamma (PPARγ) in tumor initiation and progression, emphasizing the relationship between this isoform and the cellular and molecular mechanisms …
Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor that is a vital regulator of adipogenesis, γ γ insulin sensitivity, and lipid metabolism. Activation of PPAR by antidiabetic …
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