2022年3月1日 · There are two main PPARγ isoforms, but the specific functions of each are not established. Here we generated mouse lines in which endogenous PPARγ1 and PPARγ2 were epitope-tagged to interrogate isoform-specific genomic binding, and mice deficient in either PPARγ1 or PPARγ2 to assess isoform-specific gene regulation.

2022年8月1日 · Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. Originally described as “orphan nuclear receptors”, they can bind both natural and synthetic ligands acting as agonists or antagonists.

2016年6月10日 · There are three known PPAR isotypes (PPARα, PPARβ/δ and PPARγ) that have been identified in various species and are structurally homologous 4. Different PPAR isotypes display distinct...

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that are involved in lipid metabolism, differentiation, proliferation, cell death, and inflammation. Three subtypes have been identified: PPAR-alpha, -delta, and -gamma. We have previously shown presence of PPAR-ga …

PPARs are ligand-activated transcription factors that form a subfamily of the nuclear receptor superfamily. This PPAR subfamily consists of three isotypes: PPAR-α (NR1C1), PPARβ/δ (NR1C2) and PPARγ (NR1C3). PPARs heterodimerize with members of the RXRs and as such regulate gene expression.

2012年8月9日 · We show, using in vitro analysis, lipidomics and in vivo animal models that PPAR γ isoforms control overlapping and distinct metabolic programs in prostate epithelia that lead to functional...

Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptor / ligand-activated transcription factors superfamily. PPAR subfamily consists of 3 subtypes: PPAR-α, -β/δ, and -γ. PPARs form heterodimers with a retinoid X receptor (RXR) and bind to specific PPAR-responsive elements (PPREs) to regulate target gene expression.

Here, we review the role of PPAR gamma (PPARγ) in tumor initiation and progression, emphasizing the relationship between this isoform and the cellular and molecular mechanisms involved in the antineoplastic effect of iodine on mammary cancer.

Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor that is a vital regulator of adipogenesis, γ γ insulin sensitivity, and lipid metabolism. Activation of PPAR by antidiabetic thiazolidinediones (TZD) reverses γ insulin resistance but also leads to weight gain that limits the use of these drugs.