2022年3月1日 · There are two main PPARγ isoforms, but the specific functions of each are not established. Here we generated mouse lines in which endogenous PPARγ1 and PPARγ2 …

2022年8月1日 · Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-1 gene independently of PPAR …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. Originally described as “orphan nuclear receptors”, they can bind both natural and …

2016年6月10日 · There are three known PPAR isotypes (PPARα, PPARβ/δ and PPARγ) that have been identified in various species and are structurally homologous 4. Different PPAR …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that are involved in lipid metabolism, differentiation, proliferation, cell death, and inflammation. Three …

PPARs are ligand-activated transcription factors that form a subfamily of the nuclear receptor superfamily. This PPAR subfamily consists of three isotypes: PPAR-α (NR1C1), PPARβ/δ …

2012年8月9日 · We show, using in vitro analysis, lipidomics and in vivo animal models that PPAR γ isoforms control overlapping and distinct metabolic programs in prostate epithelia that lead to …

Peroxisome proliferator-activated receptors (PPARs) are members of nuclear receptor / ligand-activated transcription factors superfamily. PPAR subfamily consists of 3 subtypes: PPAR-α, …

Here, we review the role of PPAR gamma (PPARγ) in tumor initiation and progression, emphasizing the relationship between this isoform and the cellular and molecular mechanisms …

Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor that is a vital regulator of adipogenesis, γ γ insulin sensitivity, and lipid metabolism. Activation of PPAR by antidiabetic …