2014年9月30日 · Peroxisome proliferator-activated receptor alpha (PPARα) ligands have been reported to suppress cancer growth. However, the role of PPARα in hepatocarcinogenesis remains unclear. We investigated the functional significance of PPARα in HCC.

2024年7月26日 · Overall, our study demonstrated that AQP3 could regulate the proliferation, migration, and glycometabolism of tumor cells by modulating M2 macrophages polarization through the PPAR-γ/NF-κB axis...

Peroxisome proliferator-activated receptor (PPAR) alpha, a member of the ligand-activated nuclear receptor superfamily, plays an important role in lipid metabolism and glucose homeostasis and is highly expressed in the kidney. The present studies were aimed at testing the hypothesis that PPARalpha k …

Accumulating data suggesting that Vitamin D3 could be of a potential therapeutic value for non-alcoholic fatty liver disease (NAFLD) ,but its underlying mechanisms are still under research .Vitamin D3 up regulates PPAR-α and downstream gene nuclear factor-kappa-B inhibitor subunit-alpha (NFKBIA) which may represent a novel strategy for the ...

2015年12月1日 · Effects of treatment with Vitamin D on liver tissue oxidative stress markers PPAR-α and NFKBIA mRNA expression and NAFLD activity score: …

2015年5月5日 · In current study, we investigated whether TZDs improve endothelial IR induced by high glucose concentration or hyperglycemia via a non-canonical PPARγ-dependent nuclear factor-kappa B (NF-κB) trans-repression pathway.

该基因编码 NF-kappa-B 抑制剂家族的成员，该家族包含多个锚蛋白重复结构域。 编码的蛋白质与 REL 二聚体相互作用，抑制参与炎症反应的 NF-kappa-B/REL 复合物。 编码的蛋白质通过核定位信号和 CRM1 介导的核输出在细胞质和细胞核之间移动。 已在伴有 T 细胞免疫缺陷的常染色体显性遗传病的外胚层发育不良无汗症中发现该基因的突变。 [RefSeq 提供，2011 年 8 月] This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat …

2023年3月13日 · Here, we demonstrated that lysine-specific demethylase 5B (KDM5B), a classical transcriptional repressor in stem cell development and cancer, was required for the full activation of NF-κB signaling...

Conclusion: Vitamin D3 attenuates NASH in HCHFD rat model by attenuation of redox state and up regulation of PPAR-α and its downstream gene NFKBIA in liver tissues Keywords Vitamin D3 HCHFD Nonalcoholic Steatohepatitis PPAR-α NFKBIA. Bull. of Egyp. Soc. Physiol. Sci.

2024年3月4日 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the interaction...