2014年9月30日 · Peroxisome proliferator-activated receptor alpha (PPARα) ligands have been reported to suppress cancer growth. However, the role of PPARα in hepatocarcinogenesis …

2024年7月26日 · Overall, our study demonstrated that AQP3 could regulate the proliferation, migration, and glycometabolism of tumor cells by modulating M2 macrophages polarization …

Peroxisome proliferator-activated receptor (PPAR) alpha, a member of the ligand-activated nuclear receptor superfamily, plays an important role in lipid metabolism and glucose …

Accumulating data suggesting that Vitamin D3 could be of a potential therapeutic value for non-alcoholic fatty liver disease (NAFLD) ,but its underlying mechanisms are still under research …

2015年12月1日 · Effects of treatment with Vitamin D on liver tissue oxidative stress markers PPAR-α and NFKBIA mRNA expression and NAFLD activity score: …

2015年5月5日 · In current study, we investigated whether TZDs improve endothelial IR induced by high glucose concentration or hyperglycemia via a non-canonical PPARγ-dependent …

该基因编码 NF-kappa-B 抑制剂家族的成员，该家族包含多个锚蛋白重复结构域。 编码的蛋白质与 REL 二聚体相互作用，抑制参与炎症反应的 NF-kappa-B/REL 复合物。 编码的蛋白质通过核定 …

2023年3月13日 · Here, we demonstrated that lysine-specific demethylase 5B (KDM5B), a classical transcriptional repressor in stem cell development and cancer, was required for the …

Conclusion: Vitamin D3 attenuates NASH in HCHFD rat model by attenuation of redox state and up regulation of PPAR-α and its downstream gene NFKBIA in liver tissues Keywords Vitamin …

2024年3月4日 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We …