This includes a role in mediating skin and pilosebaceous unit homoeostasis: PPARs appear to be essential for maintaining skin barrier permeability, inhibit keratinocyte cell growth, promote keratinocyte terminal differentiation and regulate skin inflammation.

The PPAR family, through its ability to modulate inflammatory response and antioxidant defense, can modulate the balance between MMP activity and collagen expression to maintain skin homeostasis and counteract skin aging.

2007年8月1日 · The present review summarizes our current knowledge of PPAR functions in rodent and human skin. The roles of PPARα, β and γ in the healthy skin, including embryonic development, adult homeostasis, skin appendages, and normal skin repair are reviewed first.

过氧化物酶体增殖激活受体(ppar)是配体激活的转录因子，属于核激素受体家族。s ppar具有s3种亚型： ppar、αpparβ/δ和pparγ，具有不同组织分布和细胞功能。3种ppars亚型均在皮肤中有分布，参与

2015年2月3日 · This includes a role in mediating skin and pilosebaceous unit homoeostasis: PPARs appear to be essential for maintaining skin barrier permeability, inhibit keratinocyte cell growth, promote keratinocyte terminal differentiation and regulate skin inflammation.

2012年9月10日 · Because of their diverse biologic activities on keratinocytes and other skin cells, PPARs represent a major research target for the understanding and treatment of many skin diseases. PPARs act especially on the main morphologic features of psoriasis and therefore may have clinical relevance in its treatment.

The present review summarizes the current knowledge of PPAR functions in various skin disorders particularly those involving inflammation and epidermal hyperproliferation (i.e., psoriasis, atopic dermatitis, acne, scleroderma, skin malignancies). Key words: PPAR, dermatology, inflammation, atopic dermatitis, psoriasis, scleroderma, cancer ...

过氧化物酶体增殖物激活受体 （PPAR）是多向性调控巨噬细胞参与屏障修复每个阶段的转录因子，属于细胞核激素受体超级家族，有PPARα、PPARγ以及PPARβ/δ三个亚型。 PPAR的三种亚型在人体诸多器官中表达，如肝脏、肾脏等，且有其特异性，而人体角质细胞却同时表达PPARα、PPARγ以及PPARβ/δ三个亚型。 正常情况下，表皮中PPAR的表达量低，而当皮肤受损时，PPAR的表达量增加，参与皮肤屏障的修复进程。 PPARα参与炎性期早期的皮肤修 …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate lipid, glucose, and amino acid metabolism. More recently, PPARs and corresponding ligands have been shown in skin and other organs to regulate important cellular functions, including cel …

2024年6月19日 · Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor expressed in many tissues, including skin, where it is essential for maintaining skin barrier permeability, regulating cell proliferation/differentiation, and modulating antioxidant and inflammatory responses upon ligand binding.