
The PPARgene database - Home
PPARgene database is not only a resource that curated the experimentally verified PPAR-α, -β/δ, and -γ target genes but also a platform that integrated tool(s) for predicting novel PPAR target genes.
PPARα: An emerging target of metabolic syndrome, …
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that is involved in lipid metabolism of various tissues. Different metabolites of fatty acids and agonists like fibrates activate PPARα for its transactivative or repressive function.
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Integrated physiology and systems biology of PPARα
2014年7月1日 · The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARα in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARα, with a focus on liver.
The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: …
Peroxisome proliferator-activated receptor-delta (PPAR-δ), one of three members of the PPAR group in the nuclear receptor superfamily, is a ligand-activated transcription factor. PPAR-δ regulates important cellular metabolic functions that contribute to maintaining energy balance.
PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
2018年3月20日 · This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders.
PPARgene: A Database of Experimentally Verified and ... - PubMed
Upon ligand binding, PPARs activate target gene transcription and regulate a variety of important physiological processes such as lipid metabolism, inflammation, and wound healing. Here, we describe the first database of PPAR target genes, PPARgene.
PPARγ phase separates with RXRα at PPREs to regulate target …
2022年4月26日 · Peroxisome proliferator-activated receptor (PPAR)-γ is a key transcription activator controlling adipogenesis and lipid metabolism. PPARγ binds PPAR response elements (PPREs) as the obligate...
Molecular mechanism of PPARα action and its impact on lipid …
2015年3月1日 · In this review, we discuss the transcriptional activation and repression mechanisms by PPARα, the spectrum of target genes and chromatin-binding maps from recent genome-wide studies, paying particular attention to PPARα-regulation of hepatic fatty acid and plasma lipoprotein metabolism during nutritional transition, and of the inflammatory respo...
Peroxisome proliferator-activated receptor alpha target genes
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. PPARα serves as a molecular target for hypolipidemic fib …
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