2024年2月17日 · This study found that Ppg prevented LPS-induced skull osteolysis by inhibiting the expression of inflammatory cytokines and osteoclast production. In vitro, Ppg blocked the RANKL-induced generation of osteoclasts, the development of pseudopodia bands, …

本研究提出Ppg通过抑制炎性细胞因子的表达和破骨细胞的产生来预防LPS诱导的炎性骨溶解，从而成为治疗炎症性骨溶解的一种新疗法。 体外实验证明Ppg阻断RANKL诱导的破骨细胞的产生和骨吸收，还通过抑制NFATc1信号通路来减弱FATc1、c-Fos、CTSK和Atp6v0d2蛋白的表达。

2024年2月17日 · This study found that Ppg prevented LPS-induced skull osteolysis by inhibiting the expression of inflammatory cytokines and osteoclast production. In vitro, Ppg blocked the RANKL-induced...

1999年7月1日 · Proteophosphoglycan (PPG) is a newly described mucin-like glycoprotein found on the surface of Leishmania major promastigotes and secreted in the culture supernatant. We show here that antigenically similar PPGs are present in several Leishmania species.

在体内，Ppg 减少了骨骼表面破骨细胞的数量，并抑制了 LPS 诱导的颅骨骨溶解。 这些结果表明 Ppg 可以作为一种新的替代疗法，通过抑制炎症和破骨细胞来治疗炎症性骨溶解。

2024年11月1日 · After inhibiting CSE activity with dl-propargylglycine (PPG i. p.), the renal tissue pathology in LPS-induced AKI mice was further exacerbated, leading to enhanced activation of the PERK/Bax-Bcl2 pathway.

2023年7月20日 · This study found that Ppg prevented LPS-induced skull osteolysis by inhibiting the expression of inflammatory cytokines and osteoclast production. In vitro, Ppg blocked the RANKL-induced...

This study found that Ppg prevented LPS-induced skull osteolysis by inhibiting the expression of inflammatory cytokines and osteoclast production. In vitro, Ppg blocked the RANKL-induced generation of osteoclasts, the development of pseudopodia bands, and bone resorption.

2016年11月24日 · Herein, we concluded that CCK-8 alleviated the ALI induced by LPS via regulating the catalytic activity of cystathionine γ-lyase (CSE) and the formation of H 2 S. This work provides new medicine-designed target for clinical doctor to prevent and cure ALI.

This study found that Ppg prevented LPS-induced skull osteolysis by inhibiting fl the expression of inammatory cytokines and osteoclast production. In vitro, Ppg blocked the RANKL-induced...