Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels.

蛋白酶3(pr3)是抗中性粒细胞胞浆抗体(anca)的主要靶抗原之一，与anca结合形成anca的胞浆型抗体—抗蛋白酶3抗体，而anca是针对中性粒细胞和单核细胞胞浆蛋白的自身抗体。

c-ANCAs, or PR3-ANCA, or antineutrophil cytoplasmic antibodies, are a type of autoantibody, an antibody produced by the body that acts against one of its own proteins. These antibodies show a diffusely granular, cytoplasmic staining pattern under microscopy .

2022年4月9日 · 其中抗PR3抗体现已证实为韦格纳肉芽肿（WG）的标志性抗体，其荧光模型以cANCA为主，特异度为90%；抗MPO抗体的荧光模型以pANCA为主，其主要与显微镜下多血管炎（MPA）、变应性肉芽肿性血管炎（CSS）和原发性坏死性新月体型肾小球肾炎相关。 与HLE、LF等靶抗原相关的疾病包括系统性红斑狼疮（SLE）、类风湿关节炎（RA）、干燥综合征（SS）、炎症性肠病、肺间质纤维化等多种非血管炎性结缔组织病，以及慢性肾炎、慢性胃 …

2019年11月13日 · Tests for antineutrophil cytoplasmic antibodies (ANCA, pANCA, cANCA, MPO, PR3) may be used to help diagnose autoimmune disorders, such as vasculitis or inflammatory bowel disease.

2024年8月11日 · Both ANCA-myeloperoxidase (MPO) and ANCA-proteinase 3 (PR3) are enzymes present in peroxidase-positive granules, and MPO is the most prevalent granular protein. PR3 is important for serving as a hematopoietic regulator …

Anti-PR3 antibodies, also referred to as Proteinase 3 antibodies or PR3-ANCA, are specific autoantibodies that target proteinase 3, an enzyme found in certain immune cells. These antibodies are primarily used to diagnose and monitor autoimmune diseases, particularly those within the ANCA-associated vasculitis (AAV) spectrum.

2022年3月11日 · An antineutrophil cytoplasmic antibodies (ANCA) test is a blood test that detects ANCAs in your blood. ANCAs are proteins made by the immune system that mistakenly target neutrophils, infection-fighting white blood cells.

2015年10月17日 · 抗中性粒细胞抗体（ANCA）直接针对蛋白酶 3（PR3）或髓过氧化物酶（MPO）。 在过去的几十年中又有不断涌现的证据来证明 PR3-ANCA 相关性血管炎（PR3-AAV）和 MPO-ANCA 相关性血管炎（MPO-AAV）之间的差别。 来自荷兰马斯特里赫特大学实验和临床免疫学的 Marc Hilhorst 教授在 JASN 上发表综述讨论了这两种小血管受累的血管炎之间的差别，我们一起来学习一下。 抗中性粒细胞抗体（ANCA）在 50 多年前首次被描述。 稍后这 …

2020年8月27日 · Most cases of granulomatosis with polyangiitis and microscopic polyangiitis are characterized by anti-neutrophil cytoplasmic antibodies (ANCAs) directed to either leukocyte proteinase 3 (PR3)...