2012年2月9日 · Our results show that PRC1 is required for microtubule polarization and the recruitment of cytokinetic factors during monopolar cytokinesis, suggesting that PRC1 contributes to microtubule organization regardless of orientation.

PRC1 interacts with several midzone components, including the microtubule plus-TIP binding protein CLASP1 which promotes microtubule growth (Liu et al., 2009; Al-Bassam et al., 2010; Maton et al., 2015; Aher et al., 2018).

PRC2 能够识别目标位点并催化 H3K27 三甲基化，可以通过 H3K27me3与 cPRC1 通信，并且，PRC2 的激活还使得H3K27me3 能沿染色质传播。 cPRC1 （canonical PRC1）也会支持细胞核中polycomb染色质结构域的扩散。 即使不在染色体同一区域，polycomb染色质域也可以在 3D 空 …

Polycomb复合体（PcG）是参与构建这种染色质抑制模式的关键蛋白质家族之一，它主要包括PRC1和PRC2两个分支。 经典的PRC1复合体，通过在生物体内及细胞内聚集，有助于维持基因的抑制状态 (2)。

2024年10月11日 · By 22 fertilizing M. musculus eggs with sperm from other mouse species, we show that species-specific 23 satellite sequences differ in their ability to recruit PRC1 and form H2Aub. This satellite-DNA mediated 24 increase in PRC1 heterochromatin leads to reduced CPC recruitment and increased microtubule 25 forces on kinetochores.

2016年5月1日 · PRC1 is able to cross-link and bundle microtubules and is transported to the spindle midzone by KIF4A [35], [36], [37], [38], [39]. The formation of the PRC1/KIF4A complex is prevented by cyclin-dependent kinase 1 (Cdk1) phosphorylation in metaphase [36], but after anaphase onset this interaction is instead promoted through Aurora B ...

2017年1月6日 · The protein required for cytokinesis 1 (PRC1), kinesin KIF4A, the chromosomal passenger complex (CPC) and Centralspindlin, are all essential structural and functional components of cytokinesis.

2024年10月11日 · This satellite-DNA mediated increase in PRC1 heterochromatin leads to reduced CPC recruitment and increased microtubule forces on kinetochores. Our results provide a direct link between satellite DNA composition and pericentromere function in the zygote, when epigenetic pathways maintaining pericentromere heterochromatin are absent.

2023年8月18日 · PRC1 associates with microtubule motors to stabilize the anaphase central spindle, however how they interact remains elusive. This study reveals the molecular basis for the cell cycle regulation of mitotic motor‐PRC1 complexes to organize antiparallel microtubule bundle, and to ensure central spindle integrity, midbody assembly and cytokinesis.

2023年7月19日 · PRC1 regulates midzone length by recruiting the kinesin Kif4a, which suppresses the elongation of midzone microtubule plus-ends (Hu et al., 2011; Nunes Bastos et al., 2013; Subramanian et al.,