2024年12月25日 · PRDM1 (PR/SET Domain 1) is a Protein Coding gene. Diseases associated with PRDM1 include Myeloma, Multiple and Plasmablastic Lymphoma. Among its related …

2022年12月12日 · Herein, we identify that tumoral Prdm1 overexpression inhibits cell growth in immune-deficient mouse models. Further, tumoral Prdm1 overexpression upregulates PD-L1 …

The gene encoding the human BLIMP1, prdm1, is located on chromosome 6q21, a locus frequently deleted in lymphoid tumors. BLIMP1 is able to silence its target genes in a context …

PRDM1 and PRDM2, initially identified as Blimp-1 (B lymphocyte-induced maturation protein-1) and RIZ (Retinoblastoma interacting zinc finger protein) respectively, have two promoters that …

2020年12月14日 · Background: PR domain zinc finger protein 1 (PRDM1) is a regulator of both B cell and T cell differentiation and plays a critical role in immunosuppression. Its role in tumor …

2022年4月7日 · PRDM1 disruption promoted the expansion of less differentiated memory CAR-T cells in vivo, which enhanced T-cell persistence and improved therapeutic efficacy in multiple …

PRDM1 (BLIMP1), a master transcriptional regulator with a PR/SET domain that binds to specific DNA targets via its zinc fingers domains (Morgan et al., 2012), controls DNA binding, nuclear …

2020年12月15日 · Background: PR domain zinc finger protein 1 (PRDM1) is a regulator of both B cell and T cell differentiation and plays a critical role in immunosuppression. Its role in tumor …

2025年2月8日 · PRDM1 levels are associated with the clinical diseases of chronic HBV infection. Highly elevated PRDM1 levels are discriminative of hepatocellular carcinoma(HCC) from other …

2019年11月13日 · PRDM1 bound a large number of genes in the NK or T cell receptor signaling pathway, which are employed during NK cell activation. In addition, several genes encoding …