2017年1月16日 · ERAD genes found to be upregulated in prostate cancer tissues and silencing expression of Hrd1, SVIP, and gp78 reduced the in vitro migration and malignant transformation of LNCaP cells.

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Endoplasmic reticulum-associated degradation (ERAD) is an essential process that removes misfolded proteins from the ER, preventing cellular dysfunction and disease. While most of the key components of ERAD are known, their specific localization remains a mystery.

ERAD genes found to be upregulated in prostate cancer tissues and silencing expression of Hrd1, SVIP, and gp78 reduced the in vitro migration and malignant transformation of LNCaP cells.

2022年11月29日 · More strikingly, we found progesterone regulates AR signaling by modulating the nuclear transactivation of AR. Herein, we defined that progesterone hormone positively regulates ERAD and UPR mechanisms in prostate cancer cells and that progesterone contributes to the molecular biology of prostate cancer by regulating androgenic signaling.

The expression levels of ERAD components, AR and PSA levels in prostate cell lines were determined by immunoblotting. Actin was used as the loading control in all immunblotting analyses in this...

2022年9月27日 · New research has uncovered an important role for the UPR in prostate cancer tumorigenesis and crosstalk between the UPR and androgen receptor signalling pathways. With an improved understanding of...

2023年9月1日 · Our results showed that AR, endogenous PSA and secreted PSA levels induced by T3 were effectively reversed by bicalutamide treatment. As expected, R1881 strongly stimulated PSA and AR levels and bicalutamide largely limited this stimulation.

2023年1月25日 · We found that estrogens strongly regulated the ERAD components and IRE1⍺ branch of UPR by Er⍺/β/AR axis. Besides, estrogenic signaling rigorously regulated the tumorigenicity of prostate cancer cells by promoting c-Myc expression and epithelial-mesenchymal transition (EMT).

准化表观扩散系数值, 即ADCn(ADC 病灶/ADC 外周带)。比较ADCn、PSAD 在两组间差异是否具有统计学意义, 采用受试者工作特性曲线(ROC)比较�. 者对 PI-RADS v2.1 评分3 分病灶中PCa 的诊断效能。 结果: 年龄、PSA 在两组间差异无统计学意义;PCa 组的ADCn小于非PCa 组. (0.52 vs. 0.69),PCa 组的PSAD 大于非PCa 组(0.28 vs. 0.18)。ADCn、PSAD 诊断PCa的ROC曲线下面积 AUC、 敏感度、 特异度分别为0.849、 5.2%、81.6%,0.813、85.0%、78.4%,ADCn 表现的 …