PSGL-1 is a novel macrophage checkpoint in immuno-oncology.
2020年5月25日 · Our work demonstrates that targeting PSGL-1 via an antagonistic antibody re-polarizes human primary M2 macrophages to a more M1-like state both phenotypically and …
PSGL-1 Blockade Induces Classical Activation of Human Tumor …
2023年10月26日 · PSGL-1 blockade via an antagonistic antibody repolarized M2 macrophages in vitro and induced a broad proinflammatory immune response in multicellular in vitro assays …
Targeting the P-selectin/PSGL-1 pathway: discovery of
2024年9月1日 · The P-selectin/PSGL-1 axis lies at the nexus of the innate immune system, coagulation and complement cascades, platelet and endothelial activation, and the fibrinolytic …
免疫细胞治疗再增一员猛将：PSGL-1重编巨噬细胞刺激免疫应答攻 …
2019年11月4日 · Verseau将PSGL-1（P-选凝素糖蛋白配基-1）确定为研究的MCM计划的首要目标靶点，利用其功能将巨噬细胞重编程为促炎状态，激活T细胞并吸引其他免疫细胞协同发挥更 …
877 PSGL-1 blocking antibodies repolarize tumor associated macrophages ...
One new macrophage repolarizing target, PSGL-1 (P-selectin glycoprotein ligand-1), is expressed at high levels on suppressive tumor-associated macrophages (TAMs) and in vitro …
PSGL-1: A New Player in the Immune Checkpoint Landscape
PSGL-1 has also been shown to regulate localization of macrophages, dendritic cells, and B cells in the lamina propria at steady state [22]. Additionally, PSGL-1 mediates adhesion of …
862 Targeting PSGL-1, a novel macrophage checkpoint, …
We show that targeting PSGL-1 via an antagonistic antibody repolarized M2 macrophages to a more M1-like state, both phenotypically and functionally as assessed in primary in vitro …
PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage …
2012年9月21日 · By profiling differentially regulated and paired plasma membrane protein genes, we showed that PSGL-1 (P-selectin glycoprotein ligand-1)/selectins and ICAM-1/CD18 played …
We show that targeting PSGL-1 via an antagonistic antibody repolarized M2 macro-phages to a more M1-like state, both phenotypically and func-tionally as assessed in primary in vitro …
(PDF) 862 Targeting PSGL-1, a novel macrophage ... - ResearchGate
2020年11月1日 · We show that targeting PSGL-1 via an antagonistic antibody repolarized M2 macrophages to a more M1-like state, both phenotypically and functionally as assessed in …