2022年12月1日 · In this study, a new strategy to promote tissue repair and tissue-to-biomaterial integration by M1-to-M2 macrophage transition using artificial apoptotic cell mimetics (phosphatidylserine liposomes; PSLs) was developed using bone as a model tissue.

2011年4月4日 · Phosphatidylserine (PS)-containing liposomes (PSLs) strongly inhibit inflammatory bone loss in adjuvant arthritic (AA) rats. This effect was attributed to the inhibition of...

This study demonstrates the advantages of local M1-to-M2 macrophage polarization induced by PSL-multilayers constructed on implants for effective bone regeneration and osseointegration (bone-to-implant integration). Mechanistically, M2 macrophages promote osteogenesis but inhibit osteoclastogenesis, and M1 macrophages vice versa.

在本研究中，为了模拟 MGF-E8，制备了呈递 RGD 肽的 PSL（RGD-PSL），并研究了它们对巨噬细胞的免疫调节作用和大鼠颅骨缺损的骨组织再生。 RGD 肽增强了巨噬细胞对 PSL的吞噬作用，尤其是当 PSL 含有 3% RGD 时。

本研究旨在探讨磷脂酰丝氨酸脂质体（PSL）和含阿仑膦酸钠的磷脂酰丝氨酸脂质体（AL-PSL）对改善甲基强的松龙（MP）诱导的大鼠骨质疏松症的作用。

目的：探究牛奶外泌体（mEXO）减少泼尼松龙（PSL）治疗杜兴肌肉萎缩症（DMD）的药物不良反应的效果。 方法：将超速离心法收集的mEXO与PSL共孵育得到生物纳米药物（mEXOPSL）；通过高效液相色谱（HPLC）检测药物装载效率；对DMD模型 mdx小鼠给予口服治疗；监测mdx小鼠体重和体长变化，评估mEXO减轻PSL引起的生长抑制不良反应的效果，利用苏木素-伊红（HE）染色和micro-CT分析骨体积分数（BV/TV）、骨小梁数目（Tb.N）、骨小 …

In this study, to mimic MGF-E8, PSLs presenting RGD peptide (RGD-PSLs) were prepared, and their immunomodulatory effects on macrophages and the bone tissue regeneration of rat calvarial defects were investigated. RGD peptides enhanced the phagocytosis of PSLs by macrophages, especially when the PSLs contained 3% RGD.

Phosphatidylserine (PS)-containing liposomes (PSLs) strongly inhibit inflammatory bone loss in adjuvant arthritic (AA) rats. This effect was attributed to the inhibition of osteoclastogenesis through the secretion of prostaglandin E (2) and transforming growth factor-β1 by osteoclast precursors after …

2022年2月28日 · PSL-Cur can significantly increase the thickness and volume of cortical and trabecular bone mass as well as the mechanical bone strength in animals. Experimental findings proposed PSL-Cur consumption as a proper and safe supplementary medication in the controlling of bone loss in patients with a high risk of osteoporosis.

鉴于此，为了模拟 MGF-E8，首尔大学Hyeong-Cheol Yang等人制备了呈递 RGD 肽的 PSL（RGD-PSL），并研究了它们对巨噬细胞的免疫调节作用和大鼠颅骨缺损的骨组织再生。