High-performance liquid chromatography (HPLC) coupled with a radio detector is the preferred semi-quantitative method for determining radiochemical purity of [177 Lu]Lu-PSMA (Gillings et …

2022年12月1日 · Here we developed and validated a simple and reproducible radio-UV-HPLC method for the QC of [68 Ga]Ga-PSMA-11 with shorter runtime as well as an easily found …

The “gold standard” ligand for PSMA imaging is Glu-NH-CO-NH-Lys (Ahx)- 68 Ga-HBED-CC ( [68 Ga]Ga-PSMA-HBED-CC) characterized by a high-affinity chelator for Gallium-68 (logK = 38.5) …

2022年9月27日 · During HPLC method development for quality control of [177 Lu]Lu-PSMA-I&T, we noticed an unpredictable variability in peak area and height with replicate measurements. …

2022年4月24日 · 由于没有专论177Lu-PSMA-1 在欧洲药典中，我们根据改编自 ICH Q2 的 EANM 建议验证分析方法。 在本研究中描述了 HPLC 和 TLC 的特异性、线性、准确度、精密度、中 …

2021年3月24日 · The nature of the side product was investigated by adding chelators, such as EDTA, to PSMA-11 solutions and using the combination of UHPLC-HRMS. The results led to …

2023年3月27日 · The described HPLC method for quality control of [177 Lu]Lu-PSMA I&T without the addition of trifluoroacetic acid shows excellent analytical results, which are in line with …

Background: Prostate-specific membrane antigen (PSMA) has shown to be a promising agent for prostate cancer imaging under PET-CT. With the automation in radiolabeling with 68Ga, using …

2022年9月27日 · During HPLC method development for quality control of [¹⁷⁷Lu]Lu-PSMA-I&T, we noticed an unpredictable variability in peak area and height with replicate measurements. After …

2021年2月25日 · For the PET imaging of prostate cancer, radiotracers targeting the prostate-specific membrane antigen (PSMA) are nowadays used in clinical practice. [18F]PSMA-1007, …