aPS/PT testing may help identify APS in patients with thrombosis or pregnancy loss in whom APS is strongly suspected but conventional antiphospholipid testing is repeatedly negative.

2024年8月19日 · The presence of elevated and persistent aPS/PT IgG and IgM antibodies (with or without lupus anticoagulant activity) may serve as a risk marker of thrombotic events in patients with certain autoimmune diseases, including antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE).

2019年7月4日 · aPS / PT IgM 和 IgG 是具有高灵敏度和特异性的检测，可用于补充现有的磷脂检测项目。 除此之外 aPS/PT 还可用于评估抗凝治疗患者的病程，此检测项目不受抗凝药物的影响。

Results are reported in IgG and IgM units. A positive result indicates the presence of PS–PT IgG or IgM antibodies and suggests the possibility of certain autoimmune disease thrombotic disorders, such as APS, or those secondary to systemic lupus erythematosus or other lupus-like thrombotic diseases.

Studies of aPS/PT antibodies have shown a strong correlation to clinical manifestations and LA. We aimed to study the value and the persistence of aPS/PT IgG and IgM antibodies in a cohort of consecutive patients with clinical suspicion of APS and their utility as thrombotic risk markers.

2023年2月1日 · We recruited 222 patients with positive LA and estimated their aPS/PT, anticardiolipin (aCL), anti-β2-glycoprotein I (aβ2GPI), and anti-β2GPI domain I (anti-D1) antibody (IgM and IgG) titers and PL-dependent clotting time.

Laboratory criteria include the presence of persistent antiphospholipid antibodies (aPL) such as lupus anticoagulant (LA), anticardiolipin (aCL) IgG/IgM or anti-beta-2-glycoprotein-I (aB2GPI) IgG/IgM .

Phosphatidylserine/Prothrombin (PS/PT) Antibodies (IgG, IgM) - Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogenous group of autoantibodies known as anti ...

2023年5月16日 · 抗pspt属于抗磷脂抗体，抗磷脂抗体中的抗体IgM高原因比较多，通常与支原体感染、类风湿关节炎、硬皮病等因素有关。 1、支原体感染：是介于细菌与病毒之间的一种致病菌，当支原体反复刺激人体组织时，相应的免疫系统会发生改变，从而使IgM偏高。

Prothrombin (PT) binds coagulation proteases such as “tissue factor” (TF) and “factor VII” which carries on the coagulation cascade. PT is a soluble protein that plays a role near the end of the coagulation cascade when it is converted into thrombin (insoluble form).