2022年9月27日 · The International Normalised Ratio (INR) is the PT ratio of a test sample compared to a normal PT (derived from the log mean normal prothrombin time (LMNPT) of 20 normal donors) corrected for the sensitivity of the Thromboplastin used in the test.

The ISI (International Sensitivity Index) value, determined by a given manufacturer. It measures the sensitivity of the tissue factor used in the PT analytic process. Or INR calculator will perform a quick INR check, and display the significance of your results .

INR 计算公式为： INR=PTR ISI 或 INR=antilog （ ISI × lgPTR ） PTR为所测PT的比值，ISI为其幂指数，即PTR的ISI次方所得数值为INR。 Poller设计了一个简便的列线图，在取得PTR和ISI值后，即可从图上直接查找出INR值，十分便利，国内已有介绍。

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2016年3月16日 · ISI（国际敏感指数）指实验室所用的凝血激酶试剂与国际标准的凝血激酶试剂在测定正常人和使用 VKA 患者血浆时定标曲线的斜率，一般来时，ISI 值越接近 1，其敏感度越高。 WHO 强烈建议厂家提供其凝血激酶的 ISI 值。 从 INR 的定义可以看出，它可能仅对服用 VKA 的患者具有指导意义，而对其他疾病如慢性肝炎、DIC、先天性凝血因子缺乏等，不同厂家的试剂盒测定的结果可能不具有可比性。 对此，有学者进行了研究，推出了 INRLiver、Rivaroxaban …

It is well recognized that the various prothrombin time (PT) reagents yield widely differing PT results in patients receiving oral anticoagulation. The primary purpose of the INR system is to minimize this variation, thereby improving the quality of …

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Prothrombin time (PT) is the primary method used in monitoring oral anticoagulant therapy. The prolongation of PT depends on reductions in three of the vitamin K dependent clotting factors (II, VII and X). 1,2 Changes in the PT noted in the first few days of vitamin K antagonist (VKA) therapy are primarily due to reductions in factor VII which ...

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