2024年12月25日 · PTBP1 (Polypyrimidine Tract Binding Protein 1) is a Protein Coding gene. Diseases associated with PTBP1 include Mouth Disease and Thrombophilia, X-Linked, Due To Factor Ix Defect. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Signaling by FGFR2.

Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. [5] [6] [7] This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).

Polypyrimidine tract binding protein 1 (PTBP1) contains a novel regulatory sequence, the rBH3, that binds the prosurvival protein MCL1. MiR-506 targets polypyrimidine tract-binding protein 1 to inhibit airway inflammatory response and remodeling via …

PTBP1 is a known regulator of posttranscriptional gene expression that controls messenger RNA (mRNA) splicing, translation, stability, and localization.

2023年12月22日 · Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism.

Polypyrimidine tract-binding proteins (PTBPs) are RNA binding proteins that regulate a number of posttranscriptional events. Human PTBP1 transits between the nucleus and cytoplasm and is thought to regulate RNA processes in both. However, ...

2023年7月28日 · Polypyrimidine tract binding protein 1 (PTBP1) is thought to be expressed only at embryonic stages in central neurons. Its down-regulation triggers neuronal differentiation in precursor and non-neuronal cells, an approach recently tested for generation of neurons de novo for amelioration of neurodegenerative disorders.

2023年12月22日 · Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism.

2025年2月8日 · PTBP1 is an RNA binding protein whose activity is required to maintain RIPK1 protein abundance by regulating alternative splice-site selection, controlling necroptosis. The B-cell-specific Ptbp1 deficiency causes an immunodeficiency phenotype due to defective production of antibody against both TI-2 and TD antigen.

2024年6月25日 · PTBP1 expression and methylation play an important role in a variety of cancers. PTBP1 can be used as a marker of inflammation, progression and prognosis in gliomas.