PTEN self-regulates through USP11 via the PI3K-FOXO pathway …
2019年2月7日 · Here we demonstrate that PTEN plays an unexpected role in regulating its own stability through the transcriptional upregulation of the deubiquitinase USP11 by the …
Involvement of the PTEN-AKT-FOXO3a pathway in neuronal ... - PubMed
The proapoptotic function of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphatase has been linked to its capacity to antagonize the phosphatidylinositol-3-kinase …
FOXO3a介导PTEN对DNA修复基因RAD51表达的调节作用 - 百度学术
目的 探讨转录因子foxo3a在pten调节rad51表达中的作用.方法 利用western印迹技术分析pten缺陷与否时,总foxo3a以及细胞核内foxo3a磷酸化的情况;转染外源akt到pten野生型细胞或外源 pten …
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to ... - PubMed
2013年2月7日 · Modulation of the AKT/FoxO3a/Bim signaling pathway by chemical inhibitors or RNA interference revealed that these events were critical for selenite-induced apoptosis in …
PTEN/FOXO3/AKT pathway regulates cell death and mediates
2017年7月20日 · Gene expression analysis on DLD1 cells showed upregulation of tumor suppressors PTEN and FOXO3; leading to AKT downregulation and further induction of …
PTEN/FOXO3/AKT pathway regulates cell death and mediates ... - PubMed
2017年7月20日 · We observed DLD1, HCT116 and SW620 cells die through apoptosis under simulated microgravity (SM). Gene expression analysis on DLD1 cells showed upregulation of …
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to
2013年2月7日 · We transfected cells with lipid phosphatase-dead PTEN plasmids or PTEN siRNA as well as inhibiting PTEN with SF1670 and discovered that selenite-mediated modulation of …
PTEN regulates p300-dependent hypoxia-inducible factor 1 ... - PNAS
2008年2月19日 · PTEN and FOXO3a regulate the transactivation domain of HIF-1α. Chromatin immunoprecipitation indicates that FOXO3a complexes with HIF-1α and p300 on the Glut-1 …
PI3K/PTEN/Akt通路在卵泡的生长和激活中起到关键作用 - 行业资 …
foxo3是卵泡激活的抑制分子，原本位于细胞核内，维持原始卵泡的静止形式。 FOXO3转位后，转录活性被抑制表现为原始卵泡的激活。 PTEN的作用则体现在将PIP3逆转为PIP2的负性调控 …
PTEN and FOXO3 expression in the prenatal and postnatal human …
2020年5月19日 · We report here the analysis of expression and immunolocalisation of FOXO3, pFOXO3 and PTEN throughout human ovary development both before and after birth …