Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.

2024年12月25日 · PTEN (Phosphatase And Tensin Homolog) is a Protein Coding gene. Diseases associated with PTEN include Cowden Syndrome 1 and Macrocephaly/Autism Syndrome. Among its related pathways are Prolactin Signaling and PIP3 activates AKT signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and magnesium ion binding.

The PTEN gene provides instructions for making an enzyme that is found in almost all tissues in the body. The enzyme acts as a tumor suppressor, which means that it helps regulate cell division by keeping cells from growing and dividing (proliferating) too rapidly or in an uncontrolled way.

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that is frequently altered in cancer. PTEN has phosphatase-dependent and - independent roles; and genetic alterations in PTEN lead to deregulation of protein synthesis, cell cycle, migration, growth, DNA repair, and survival signaling.

More than 30 mutations in the PTEN gene have been found to cause Bannayan-Riley-Ruvalcaba syndrome. Common features of this condition include a large head size ( macrocephaly), multiple noncancerous tumors and tumor-like growths called hamartomas, and …

2018年6月1日 · PTEN is one of the most frequently mutated tumour suppressor genes in human cancer. It was identified simultaneously by three groups in 1997 as a candidate tumour suppressor gene 1, 2 and a...

Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered as a tumor suppressor with growth and survival regulatory functions. In recent years, the function of PTEN as a metabolic regulator has attracted significant attention.

2025年1月14日 · The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is a critical tumor suppressor that plays an essential role in the development and functionality of the central nervous system. Located on chromosome 10 in humans and chromosome 19 in mice, PTEN encodes a protein that regulates …

2024年12月25日 · Gene target information for PTEN - phosphatase and tensin homolog (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

This gene has 5 transcripts (splice variants), 8 paralogues and is associated with 166 phenotypes. A single transcript chosen for a gene which is the most conserved, most highly expressed, has …