Space-filling model of the PTEN protein (blue) complexed with tartaric acid (brown) [5] Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.

2024年12月25日 · PTEN (Phosphatase And Tensin Homolog) is a Protein Coding gene. Diseases associated with PTEN include Cowden Syndrome 1 and Macrocephaly/Autism Syndrome . Among its related pathways are Prolactin Signaling and PIP3 activates AKT signaling .

The PTEN gene provides instructions for making an enzyme that is found in almost all tissues in the body. Learn about this gene and related health conditions.

磷酸酯酶与张力蛋白同源物 （英語： Phosphatase and tensin homolog，简称为 PTEN）是一种在人体中由 PTEN 基因 编码的 蛋白质 [2]。 该基因的突变是多种 癌症 进展过程的环节之一。 PTEN 通过其 磷酸酯酶 蛋白产物而行使一种 抑癌基因 的作用。 这一磷酸酯酶参与了 细胞周期 的调节，阻止细胞过快地生长与分裂 [3]。 其为 癌微RNA MIRN21 的靶之一。 该基因被鉴定为一种肿瘤抑制物，在多种癌症中往往处于变异状态。 该基因编码的蛋白质是一种磷脂酰肌醇-3,4,5-三磷 …

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that is frequently altered in cancer. PTEN has phosphatase-dependent and - independent roles; and genetic alterations in PTEN lead to deregulation of protein synthesis, cell cycle, migration, growth, DNA repair, and survival signaling.

2018年6月1日 · PTEN is one of the most frequently mutated tumour suppressor genes in human cancer. It was identified simultaneously by three groups in 1997 as a candidate tumour suppressor gene 1, 2 and a...

Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered as a tumor suppressor with growth and survival regulatory functions. In recent years, the function of PTEN as a metabolic regulator has attracted significant attention.

2025年1月14日 · The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is a critical tumor suppressor that plays an essential role in the development and functionality of the central nervous system. Located on chromosome 10 in humans and chromosome 19 in mice, PTEN encodes a protein that regulates …

2024年12月25日 · Evaluation of expression of the PTEN gene, oestrogen and progesterone receptors as diagnostic and predictive factors in endometrial cancer. Samulak D, et al. Pathol Oncol Res, 2014 Jan. PMID 24030769, Free PMC Article

PTEN基因（gene of phosphate and tension homology deleted on chromosome ten，PTEN），又称为MMAC1（mutated in multiple advanced cancer 1）和TEP1（TGF-regulated and epithelial cell -enriched phosphatase）。定位于染色体10q23.3，由9个外显子组成，编码由403个氨基酸组成的蛋白质，具有磷酸酯酶的活性。