2015年9月25日 · PTEN is physically associated with replication protein A 1 (RPA1) via the RPA1 C-terminal domain. STORM and iPOND reveal that PTEN is localized at replication sites and …

We propose that RPA1 is a target of PTEN function in fork protection and that PTEN maintains genome stability through regulation of DNA replication. Keywords : PTEN; RPA1; replication;...

The maintenance of heterochromatin rigidity by PTEN relies on its functional interaction with histones and non-histone chromatin components such as heterochromatin protein 1 (HP1). …

2019年2月1日 · PTEN is localized at replication sites, and interacts with OTU domain-containing ubiquitin aldehyde-binding proteins 1 (OTUB1) as well as RPA1 via its C-terminus. PTEN was …

2015年9月25日 · PTEN is physically associated with replication protein A 1 (RPA1) via the RPA1 C-terminal domain. STORM and iPOND reveal that PTEN is localized at replication sites and …

PTEN是迄今发现的第一个具有双重特性磷酸酶活性的肿瘤抑制基因，有 脂质磷酸酶 和 蛋白磷酸酶 双重特异性，在细胞内多条信号传导途径调控中起着重要作用，自发现以来受到众多学者 …

2020年9月25日 · Replication protein A (RPA) is the major eukaryotic ssDNA-binding protein. As such, RPA protects the transiently formed ssDNA from nucleolytic degradation and serves as …

2015年9月25日 · We show that deletion of PTEN leads to replication fork collapse and chromosomal instability upon fork stalling following nucleotide depletion induced by …

PTEN physically associates with RPA1. Lysates of HCT116 cells were immunoprecipitated with an anti-PTEN monoclonal antibody and subjected to western blotting with an anti-RPA1 antibody.

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an …