A Smad3-PTEN regulatory loop controls proliferation and ... - Nature
2017年5月19日 · We demonstrate that TGF- β triggers apoptosis of wild-type polarized endometrial epithelial cells by a Smad3-dependent activation of PTEN transcription, which results in the inhibition of...
TGFβ modulates PTEN expression independently of SMAD …
Our findings suggest that the TGFβ-PI3K-PTEN proliferative pathway is unmasked with loss of the suppressive TGFβ-SMAD pathway in colon cancer cells, converting TGFβ’s dominant role as a tumor suppressor into a tumor promoter.
PTEN基因抗癌新机制：通过编码环状RNA circPTEN1抑制肿瘤侵袭|蛋白|细胞|pten…
2022年2月8日，北京大学基础医学院尹玉新教授团队在Molecular Cancer在线发表了题为circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling 的研究论文，鉴定了一种由抑癌基因PTEN编码的环状RNA，命名为circPTEN1。circPTEN1可以干扰TGF ...
SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory ...
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway. The TGF-β pathway is widely known for ...
circPTEN1, a circular RNA generated from PTEN, suppresses …
2022年2月8日 · Our study uncovered a novel PTEN gene-generated circRNA with a tumor suppression function, and further revealed the mechanism of circPTEN1 in CRC metastasis mediated by TGF-β. The identification of circPTEN1 provides a new direction for PTEN investigation, and elucidation of circPTEN1/TGF-β/Smad sig …
TGFbeta modulates PTEN expression independently of SMAD …
TGFbeta utilizes intracellular SMADs to mediate growth suppression; however, TGFbeta-induced proliferative pathways may become more apparent when SMAD signaling is abrogated. Here, we determined regulation of the tumor suppressor PTEN by …
A positive feedback loop between SMAD3 and PINK1 in regulation …
2025年3月11日 · PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy. Previous studies on PINK1 mainly ...
Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear …
2021年10月5日 · PTEN is a protein highly altered in endometrial cancer. PTEN mutation or deficiency leads to the activation of other downstream proteins that are important to the development of cancers. In this study, we have identified the SMAD2/3 proteins as targets of PTEN deficiency.
尹玉新团队发现PTEN基因抗癌新机制：通过编码环状RNA …
2022年2月8日，北京大学基础医学院尹玉新教授团队在Molecular Cancer在线发表了题为“circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad...
PTEN mRNA、SMAD4 mRNA在肝外胆管癌中的表达及临床意义
目的通过检测第10号染色体磷酸酶和张力蛋白同源丢失基因(pten) mrna和tgf的细胞内信号转导蛋白家族(smad) mrna在肝外胆管癌中的表达,研究它们在肝外胆管癌发生发展过程中的表达特点、相互关系以及对早期诊断及预后判断的临床价值.方法应用原位杂交染色法检测42 ...