PTEN self-regulates through USP11 via the PI3K-FOXO pathway …
2019年2月7日 · Our findings therefore demonstrate that PTEN-PI3K-FOXO-USP11 constitute the regulatory feedforward loop that improves the stability and tumor suppressive activity of PTEN. …
Ubiquitin specific peptidase 11 knockdown slows Huntington’s …
2025年1月8日 · We demonstrated that USP11 downregulation promoted ubiquitination modification of PTEN and activated the AKT pathway, and PTEN overexpression reversed the …
Ubiquitin specific peptidase 11 as a novel therapeutic target for ...
2022年6月17日 · USP11 significantly restrains the tumor progression via deubiquitinating and stabilizing PTEN (prostate cancer) and VGLL4 (Renal clear cell adenocarcinoma). USP11 also …
The equilibrium of tumor suppression: DUBs as active regulators of PTEN …
2022年11月16日 · While PTEN can be targeted by HECT-type E3 ubiquitin ligases for nuclear import and proteasomal degradation, studies have shown that several deubiquitinating …
PTEN通过USP11经PI3KFOXO途径进行自我调节，稳定肿瘤抑制作用
2023年8月11日 · 因此，作者的研究结果表明PTEN-PI3K-FOXO-USP11构成了调节前馈回路，可提高PTEN的稳定性和肿瘤抑制活性。 研究内容. 1.USP11通过上调PTEN来拮抗PI3K活性. 为 …
Ubiquitin specific peptidase 11 knockdown slows Huntington's …
2025年1月8日 · We demonstrated that USP11 downregulation promoted ubiquitination modification of PTEN and activated the AKT pathway, and PTEN overexpression reversed the …
The Correlations between the Intensity of Histopathological …
2023年12月8日 · USP11 is an antagonist of PI3K due to its ability to amplify PTEN expression [5,6,7,17,21,22]. The purpose of the current study was to evaluate the relationships between …
PTEN self-regulates through USP11 via the PI3K-FOXO pathway …
Our findings therefore demonstrate that PTEN-PI3K-FOXO-USP11 constitute the regulatory feedforward loop that improves the stability and tumor suppressive activity of PTEN. PTEN is a …
PTEN self-regulates through USP11 via the PI3K-FOXO pathway to ... - PubMed
2019年2月7日 · Here we demonstrate that PTEN plays an unexpected role in regulating its own stability through the transcriptional upregulation of the deubiquitinase USP11 by the …
The equilibrium of tumor suppression: DUBs as active regulators of PTEN …
While PTEN can be targeted by HECT-type E3 ubiquitin ligases for nuclear import and proteasomal degradation, studies have shown that several deubiquitinating enzymes, …