Post-translational modification (PTM) of proteins allows cells to regulate protein functions, transduce signals and respond to perturbations. PTMs expand protein functionality and diversity, which leads to increased proteome complexity. PTM crosstalk describes the combinatorial action of multiple PT …

蛋白质翻译后修饰（Protein post-translational modifications, PTM）是指蛋白质主干链或氨基酸侧链上共价键的断裂或生成，也称为共价修饰。 这种修饰扩展了20种天然氨基酸的化学组成和信息，在各个方面对蛋白质产…

2021年4月7日 · Posttranslational modifications (PTMs) are covalent processing events that change the properties of a protein by proteolytic cleavage and adding a modifying group, such as acetyl, phosphoryl, glycosyl and methyl, to one or more amino acids (1).

2021年7月15日 · We computed pTM scores for the human proteome, in an effort to identify multi-domain predictions that could feature novel domain packings.

2022年6月16日 · Secara global, Penyakit Tidak Menular (PTM) menyebabkan 71% kematian atau sekitar 41 juta orang setiap tahun. (WHO, 2021). WHO juga menyatakan bahwa Indonesia mencapai angka 66% kematian akibat...

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We discuss the subcellular location and regulatory mechanisms that control post-translational modifications of GPCRs. The functional implications of newly discovered GPCR PTMs on receptor folding, biosynthesis, endocytic trafficking, dimerization, compartmentalized signaling, and biased signaling are also provided.

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Proteomics and post-translational modification (PTM) analyses offer new opportunities for a comprehensive understanding of pathophysiology of brain in AD. We report here multiple PTMs in patients with AD, harnessing publicly available proteomics data from nine brain regions and at three different Braak stages of disease progression.

fuz Movement (PTM),1 Pashteen has guided the movement in using nonviolent tactics in their struggle. In response to the PTM’s momentum and recent gains, the Pakistani state has used physical and administrative repression to suppress the movement and create a …