蛋白酪氨酸磷酸酶PTP1B(PTPN1)简介 - 知乎 - 知乎专栏
PTP1B 就是一个广泛存在的原型非受体 酪氨酸磷酸酶，在调节各种代谢如糖尿病肥胖或癌症如 EGF相关通路 中扮演着重要角色。 下面会从它的发现，简单结构，作用机制及作为靶点药物 …
PTPN1 - Wikipedia
PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. [6] It has also been …
蛋白酪氨酸磷酸酶 - 百度百科
PTP1B专一水解芳香族磷酸，如磷酸化酪氨酸（phosphotyrosyl，pTyr）残基上 磷酸根 的酶，通过对 胰岛素受体 或其底物上的 酪氨酸 残基去磷酸化作用，对胰岛素 信号转导 进行负调节， 组 …
Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure …
PTP1B is a ubiquitous and abundant intracellular prototypic non-receptor tyrosine phosphatase that is recognized as a major negative regulator of numerous signaling cascades of metabolic …
Protein tyrosine phosphatase 1B in metabolic diseases and drug
2024年3月22日 · Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signalling pathways, including direct negative...
Protein Tyrosine Phosphatase 1B (PTP1B): A Comprehensive …
Overexpression of protein tyrosine phosphatase 1B (PTP1B) disrupts signaling pathways and results in numerous human diseases. In particular, its involvement has been well documented …
Protein tyrosine phosphatase 1B (PTP1B) as a potential …
2022年11月1日 · Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered a direct negative regulator of several receptor and receptor-associated tyrosine …
2018年1月1日 · 本文以PTP1B的结构特点及其与T2DM和肥胖症的关系为基础，根据结合位点将PTP1B抑制剂进行分类，并对其最新 研究进展进行综述，旨在为靶向PTP1B的抗T2DM和肥 …
Protein tyrosine phosphatase 1B (PTP1B) function, structure, and ...
PTP1B is crucial in the pathogenesis of type 2 diabetes mellitus and obesity. These biological functions have made PTP1B validated as an antidiabetic and anti-obesity, and potentially …
Protein-Tyrosine Phosphatase 1B Substrates and Metabolic …
Protein-tyrosine phosphatase 1B (PTP1B) has emerged as a key regulator of signaling networks that are implicated in metabolic diseases such as obesity and type 2 diabetes. In this review, …