Using fMRI, Shin and colleagues presented unmasked happy and fearful facial expressions to subjects with PTSD and trauma-exposed subjects without PTSD . Diminished rACC, vmPFC and dorsal mPFC responses to fearful versus happy expressions were found in the PTSD group relative to trauma-exposed control subjects. rACC activation was negatively ...

2021年2月1日 · These efforts to characterize the neural signatures of PTSD via utilization of rs-fMRI connectivity data are potentially promising given the improved stability and reproducibility, low cost, and low performance demand from participants, yielding high compliance, compared with task-based fMRI.

Studies in patients with posttraumatic stress disorder (PTSD) and other psychiatric disorders related to stress have replicated findings in animal studies by finding alterations in these brain areas.

Magnetic resonance imaging (MRI) plays a primary role in both structural and functional neuroimaging for PTSD, demonstrating focal atrophy of the gray matter, altered fractional anisotropy, and altered focal neural activity and functional connectivity.

2021年1月21日 · Prior task-based functional magnetic resonance imaging (fMRI) studies have observed that activity within the amygdala, hippocampus, and prefrontal cortex...

Functional neuroimaging studies that use SPECT, PET, and fMRI have opened up a new window to uncover the mechanisms behind PTSD. The most consistent finding in many research studies to date is a relative decrease in mPFC activity, and increased amygdalar activation.

2023年9月7日 · In this retrospective study, we investigated resting-state functional MRI data collected from a total of 192 participants, 134 of whom were diagnosed with PTSD. Small functional connectivity...

2019年4月3日 · We found that a subgroup of patients with PTSD from two independent cohorts displayed both aberrant functional connectivity within the ventral attention network (VAN) as revealed by functional magnetic resonance imaging (fMRI) neuroimaging and impaired verbal memory on a word list learning task.

2023年5月25日 · Hyperactivation of amygdala is a neural marker for post-traumatic stress disorder (PTSD) and improvement in control over amygdala activity has been associated with...

2021年9月1日 · We introduce a novel end-to-end neural network that employs resting-state and task-based functional MRI (fMRI) datasets, obtained one month after trauma exposure, to predict PTSD symptoms at one-, six- and fourteen-months after the exposure.