2023年8月1日 · A promising approach for treating breast tumors in a clinical setting is a combination of immune checkpoint inhibitors and nab-paclitaxel. In this context, we evaluated the combination of a mouse antibody against programmed cell death protein 1 (PD1), anti-PD1 and POx-PTX/PLX in 4T1 model.

2018年12月31日 · To gauge the participation of tumour-derived EVs in PTX-induced mammary tumour metastasis, we used sequential ultracentrifugation to isolate EVs 30,31 from the cell culture media of unmodified...

2021年10月15日 · The multifunctional nanocomplex (HA/ siSTAT3 PPL PTX) effectively entered CD44-overexpressed 4T1 cells via an active targeting mechanism. HA shell was degraded by the concentrated hyaluronidase in the endo/lysosome and the rapid drug release was triggered by the redox micro-environment of cytoplasm.

2021年2月26日 · The carrier was applied on 4T1, MCF 7, and MCF-10A breast cell lines to evaluate its drug delivery potency and specificity. EE and LE were calculated to be 77.6% and 7.76%, respectively. MTT results revealed that aptameric SPIONs@PTX was more toxic than non-aptameric SPIONs@PTX.

The in vivo anti-tumor efficacy of PTX/TS-CS-PEG-FA, as measured by reduction in tumor volume of 4T1 mouse breast cancer injected in Balb/c mice was significantly greater than that of Anzatax®. Pharmacokinetic study in tumor bearing mice revealed that the micellar formulation prolonged the systemic circulation time of PTX and the AUC of PTX/TS ...

2017年2月27日 · 这项研究的目的是使用强免疫原性4T1小鼠乳腺癌模型探索IM的免疫药理活性，并评估其对PTX癌症反应性和疗效的影响。 该结果突出了IM在减轻乳腺癌治疗期间PTX诱导的毒性，特别是对非特异性免疫的毒性方面的潜在有益作用。 共同治疗表现出抗肿瘤作用，包括减少肿瘤生长，延长荷瘤小鼠的存活时间，增加外周血中单核细胞和淋巴细胞的数量。 在脾脏中，IM + PTX治疗增加了全淋巴细胞的比例，原因是具有CD11c +和Fc受体（CD16 / 32）低表达的特 …

The aim of this pilot study was to model the clinical stages and evaluate the response to treatment with the paclitaxel (PTX) and doxorubicin (DOX) in tumors caused by this cell line. Methods: The syngeneic tumors were developed in BALB/c female mice by 4T1 cell line.

Paclitaxel (PTX) as the most important member of the taxane family is used against a wide range of cancers including breast, ovarian and lung cancers. However, the effectiveness of PTX in...

The in vitro and in vivo bioactivities of silibinin (SB), paclitaxel (PTX) and SB and PTX in combination (SB+PTX) against murine metastatic mammary 4T1 cancer cell line were investigated. Isobologram and combination index (CI) analyses showed that SB and PTX can function synergistically in the inhib …

2022年9月1日 · Herein, a 4T1 cancer cell membrane-coated HSA nanoparticle was developed for PTX delivery (CM-HSA-PTX). The cell membrane modification strategy is used to improve stability and targeting ability to homologous cells of HSA-PTX nanoparticles simultaneously.