Dendritic Polylysine with Paclitaxel and Triptolide Codelivery for ...
2024年4月10日 · Recently, paclitaxel (PTX) was reported to increase intracellular lipid reactive oxygen species (ROS) levels, triggering cancer cell ferroptosis. Based on this, some efforts …
Reactive Oxygen Species Responsive Paclitaxel-PEG Nano-Prodrug …
2024年9月17日 · The obtained PTX prodrug polymer (PTX-PEG) can self-assemble into micelles with PTX acting as a hydrophobic core (PTX-PEG/MCs). Notably, the peroxyoxalate linkage …
树突状聚赖氨酸与紫杉醇和雷公藤甲素共递送，通过 ROS 的积累 …
最近，据报道紫杉醇（ptx）会增加细胞内脂质活性氧（ros）水平，引发癌细胞铁死亡。在此基础上，人们为改善ptx治疗非小细胞肺癌（nsclc）做出了一些努力。我们前期的研究表明，雷公 …
Metronomic and single high-dose paclitaxel treatments produce
2023年11月6日 · Here, we show how two paclitaxel (PTX) treatment methods- a single high dose and a weekly metronomic dose for four weeks, generate unique chemoresistant populations.
Self-facilitated ROS-responsive nanoassembly of heterotypic …
2019年5月28日 · Herein, we report a self-facilitated nanoassembly of a heterotypic chemo-photodynamic dimer for multimodal cancer therapy. A reactive oxygen species (ROS) …
Efficient tumor synergistic chemoimmunotherapy by self-augmented ROS ...
2023年3月16日 · In this study, a self-augmented reactive oxygen species (ROS) responsive nanocarrier with immunogenic inducer paclitaxel (PTX) and indoleamine 2,3-dixoygenase 1 …
Paclitaxel Induces the Apoptosis of Prostate Cancer Cells via ROS ...
2022年10月24日 · In summary, we demonstrate that PTX regulates the expression of HIF-1α through increased ROS accumulation, thereby promoting the activation of JNK/caspase-3 …
Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for …
2019年8月6日 · Treatment with ROS-sensitive NPs containing PTX gave an improved therapeutic effect in HeLa xenografts than their counterpart, free PTX or nab-PTX. Our data revealed a …
Advancing the therapeutic effectiveness of paclitaxel in chronic ...
1 天前 · PTX is a microtubule-stabilizing component that disrupts normal microtubule dynamics, leading to mitotic inhibition and, ultimately, inducing apoptosis in malignancies . PTX has also …
Adv Sci：深圳大学林静团队研究利用可激活的异二聚体前药酶组合 …
2024年11月24日 · 研究开发了一种可ros激活的异二聚体前药负载酶组件，用于多种治疗剂的自我促进可编程释放。 异二聚体前药NBS-TK-PTX（即NTP）由NBS、紫杉醇（PTX）和ROS响 …