第一组是CA1中的海马后投射（retrohippocampal-projecting）中间神经元，其特征是局限于 内嗅皮层 （EC）和 海马下托复合体 内（通常被称为“海马后”的区域）。第二组LRP中间神经元是背向投射（back-projecting）的中间神经元，投射“背向”CA3和齿状回（DG）的大部分 ...

2020年9月2日 · Synaptic weights from PV interneurons onto CA1 pyramidal cells follow a rate-based Hebbian plasticity rule in which the coactivation of pre- and postsynaptic neurons leads to LTD:

CA1整体均接受Schaffer氏侧支和联合纤维来自CA3的辐射层（stratum radiatum）和来自CA2的始层（stratum oriens）的投射。 此外一大特征性是有一来自嗅周皮质的纤维直接投射到CA1。

2024年11月26日 · Area CA1 is the last stage of the hippocampal trisynaptic pathway and is essential for memory formation. 28 CA1 activity is regulated by a highly diverse group of interneurons that are distributed across different layers, including a group of less-studied interneurons in the border between the stratum radiatum (SR) and the stratum lacunosum ...

2011年1月30日 · Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive...

2014年6月4日 · Using paired recordings in vitro, two-photon Ca 2+ imaging in vivo, and computational modeling, we found that parvalbumin-expressing basket cells (PVBCs) evoked greater inhibition in CA1 PCs located in the deep compared to superficial layer …

2024年1月24日 · Our data indicate unique roles for parvalbumin- and somatostatin-positive interneurons in the dentate gyrus that are distinct from those in CA1-3 and may support routing of novel information. The...

2025年1月1日 · In the CA1, microglial hyperphagocytosis of PNNs results in impaired functioning of PV-positive interneurons, leading to a decrease in the transmission of signals from PV-positive interneurons to pyramidal neurons. In addition, γ oscillations are decreased in the CA1 of hippocampus, a phenomenon attributed to E/I imbalance.

The CA1 fast-spiking PV INs with BACE1 deletion exhibited an enhanced response of postsynaptic N-methyl-D-aspartate (NMDA) receptors to local stimulation on CA1 oriens, with average intrinsic electrical properties and fidelity in synaptic integration.

2017年9月29日 · In CA1, inhibition of PV + cells disrupts phase-locked firing of PV + cells to ripples, and ripple coherence (Gan et al., 2017; Stark et al., 2014). This is consistent with the proposed role of PV + cells acting as a ‘clocking mechanism’ in circuits, ensuring that specific cell populations fire at appropriate times ( Freund and Katona, 2007 ).