A major population of neurons in the central nucleus of amygdala (CeA) send projections to the periaqueductal gray (PAG), a key midbrain structure that mediates coping strategies in response to threat or stress. While the CeA-PAG pathway has proved to be a component of descending anti-nociceptive ci …

2018年9月5日 · Chronic alcohol exposure alters cell signaling in the central nucleus of the amygdala (CeA), and the CeA is implicated in mediating alcohol dependence-related behaviors. The CeA projects to the periaqueductal gray (PAG), a region critical for descending pain modulation, and may have a role in alcohol withdrawal hyperalgesia.

2022年8月1日 · Intriguingly, an experiment on cricket hunting in mice reveals that separate CeA populations with distinct projection targets play dissociable roles in sequential predatory modes, with...

2019年5月1日 · The PAG is clearly a major output of the CeA and extended amygdala and orchestrates emotional expression. The PAG plays a key role in both the classic spinothalamic pain pathway and the emotional parabrachial pain pathway via the CeA [88].

2018年4月1日 · The CEA sends information about the expected aversive outcome to the periaqueductal grey (PAG) which in turn receives afferent sensory input about the experienced aversive stimulus. Such a signal is believed to be fed back to various subnuclei including the lateral amygdala (LA) where it modulates aversive responses of LA neurons [ 23 • ].

2024年8月22日 · Neuroplasticity in the central nucleus of the amygdala (CeA) has emerged as a mechanism for sensory and emotional-affective aspects of injury-induced pain, although evidence comes from studies conducted almost exclusively in …

据观察，RVM 投射和非投射 PAG 神经元均接收内在 PAG 和外在 CeA 突触输入，这些输入主要是 GABA 能的。 阿片类药物通过突触前 µ 受体发挥作用，抑制所有 PAG 神经元的内在和外在 GABA 能输入，尽管这种抑制在 RVM 投射神经元中更为明显。 相比之下，大麻素通过突触前 CB1 受体发挥作用，专门抑制从 CeA 到 RVM 投射 PAG 神经元的直接下行 GABA 能输入。 这些发现表明 CeA 控制 PAG 输出神经元，这些神经元通过平行的直接和间接 GABA 能途径投射到 RVM。 µ …

2019年1月1日 · What do the periaqueductal grey (PAG), local coeruleus and paraventricular nucleus have in common? Functionally, not much. However, they all receive input from a small, integral structure called the central amygdala (CeA) (Aggleton, 2000). The CeA was classically seen as a passive structure – a relay station in which information simply goes ...

2018年10月3日 · Applying anatomical labelling strategies and whole cell recordings in acute brain slice, we aimed to identify and characterize retrogradely labelled PAG-projecting CeA neurons (CeA-PAG neurons). The CeA is termed the ‘nociceptive amygdala’ (Neugebauer, 2015) as extensive research shows that CeA neurons are sensitized in models of ...

In acute brain slices, we investigated the topographical and intrinsic characteristics of retrogradely labelled CeA-PAG neurons using epifluorescence and whole-cell electrophysiology. We also measured changes to CeA-PAG neurons in the complete Freund’s adjuvant (CFA) model of inflammatory pain.