PAK3 (p21-activated kinase 2, beta-PAK) is one of three members of Group I PAK family of evolutionary conserved serine/threonine kinases. [ 5 ] [ 6 ] [ 7 ] PAK3 is preferentially expressed in neuronal cells [ 8 ] [ 9 ] and involved in synapse formation and plasticity and mental retardation .

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2024年12月25日 · PAK3 (P21 (RAC1) Activated Kinase 3) is a Protein Coding gene. Diseases associated with PAK3 include Intellectual Developmental Disorder, X-Linked 30 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Signaling by Rho GTPases and Integrin Pathway.

Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues. 该基因编码的蛋白质是一种丝氨酸-苏氨酸激酶，与 GTP 结合的 Ras 样 (P21) 、CDC2 和 RAC1 形成活化复合物。 这种蛋白质对于树突发育和与突触可塑性相关的树突棘中的快速细胞骨架重组可能是必需的。 该基因的缺陷是 X 连锁智力障碍的非综合征形式的原因。 已经鉴定出编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2017 年 7 月]

2025年1月4日 · Title: PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.

The PAK3 gene, originally cloned in the mouse (Manser et al., 1995), is a member of the family of p21-activating kinase genes. It encodes PAK3, a serine–threonine kinase with a critical role in linking Rho-GTPases to the actin cytoskeleton.

p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. potential role of PAK3 in the progression of ACTH-producing thymic carcinoid; PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features.

Plasmid Pak3 from Dr. Dong-Yan Jin's lab contains the insert Pak3 and is published in Retrovirology. 2013 Apr 26;10:47. doi: 10.1186/1742-4690-10-47. This plasmid is available through Addgene.

p21 (RAC1) 激活激酶 3： 该基因编码的蛋白可启动蛋白激酶活性和小 GTPase 结合活性。 参与轴突发生和树突棘形态发生。 在有机环状化合物和树突棘发育的细胞反应上游或细胞反应中起作用。

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1.