2023年12月19日 · PAK1 inactivates the tumor suppressor Merlin by phosphorylation at Ser 518 (68, 69), which in turn inhibits Hippo pathway MST1/2-LATS1/2–mediated phosphorylation and …

2016年8月18日 · Serine/threonine-protein kinase proteins, also known as P21-activated kinase (PAK), and the mechanosensitive factor, Yes-associated protein 1 (YAP-1) are core mediators …

2017年11月24日 · PAK1-mediated merlin phosphorylation on Ser-518 reduced merlin’s interactions with both LATS1/2 and YAP1, resulting in YAP1 dephosphorylation and nuclear …

2023年12月19日 · Both RHOA mutants stimulated the transcriptional co-activator YAP1 through actin dynamics to promote DGC progression; however, RHOA L57V additionally did so by …

粘附依赖性细胞增殖的重要途径是Hippo信号级联，其由转录因子Yes相关蛋白1（YAP1）和具有PDZ结合基序（TAZ）的转录共激活因子共同调控。 然而，细胞如何在分子水平上整合细胞外 …

两种 rhoa 突变体均通过肌动蛋白动力学刺激转录共激活因子 yap1，从而促进 dgc 进展；然而，罗奥 l57v 另外，通过激活激酶 igf1r 和 pak1 来实现这一点，这与 rhoa 诱导的 fak 介导机制不同 …

YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling pathway. In addition to important functions in normal tissue homeostasis and regeneration, YAP1 has …

2016年8月18日 · Serine/threonine-protein kinase proteins, also known as P21-activated kinase (PAK), and the mechanosensitive factor, Yes-associated protein 1 (YAP-1) are core mediators …

2017年11月11日 · PAK1-mediated merlin phosphorylation on Ser-518 reduced merlin's interactions with both LATS1/2 and YAP1, resulting in YAP1 dephosphorylation and nuclear …

2017年11月24日 · PAK1-mediated merlin phosphorylation on Ser-518 reduced merlin's interactions with both LATS1/2 and YAP1, resulting in YAP1 dephosphorylation and nuclear …