PAK4 phosphorylates and inhibits AMPKα to control glucose …
2024年8月10日 · We demonstrate that PAK4 promotes insulin resistance by phosphorylating AMPKα2 at Ser491, thereby inhibiting AMPK activity. We additionally show that skeletal …
A novel interaction of PAK4 with PPARγ to regulate Nox1 and
2017年5月22日 · We identified grade-dependent p21-activated kinases 4 (PAK4) upregulation in gliomas and further determined its role in mesenchymal transition and radioresistance. IR …
p21-activated kinase 4 inhibition protects against liver ischemia ...
Genetic or pharmacological suppression of PAK4 alleviates HIR injury. Thus, PAK4 inhibition may represent a promising intervention against I/R-induced liver injury. PAK4 phosphorylates Nrf2 …
Biological role of the PAK4 signaling pathway: A prospective ...
2023年1月1日 · PAK4 acts as a serine/threonine kinase in response to Rho GTPases, while interaction partners and substrates are rapidly extended, implying a diverse range of cellular …
PAK4 in cancer development: Emerging player and therapeutic ...
2022年10月1日 · In this paper, we systematically review the role of PAK4 in cancer, including its structure, localization, expression, upstream regulators and essential functions in cancer. We …
The role of PAK4 in the immune system and its potential …
2021年9月1日 · Together with Cdc42V12 expression, PAK4 participates in filopodia formation. PAK4 also regulates IRF and TNF-α expression levels which are involved in the immune …
PAK4 p21 (RAC1) activated kinase 4 [ (human)] - National Center …
2025年2月8日 · PAK4 downregulation decreased PPARgamma-mediated Nox1 expression and suppressed EMT in IR-treated glioma cells. miR-1271/Zic2/PAK4 axis plays an important role …
A novel interaction of PAK4 with PPARγ to regulate Nox1 and ... - PubMed
2017年9月14日 · We identified grade-dependent p21-activated kinases 4 (PAK4) upregulation in gliomas and further determined its role in mesenchymal transition and radioresistance. IR …
丝氨酸/苏氨酸蛋白激酶4生物学特性的研究进展
摘要： 丝氨酸/苏氨酸蛋白激酶4 (p21-activated kinases 4, PAK4)，是生物学界新发现的一种蛋白因子，在细胞信号转导过程中起重要作用。 研究发现PAK4与细胞凋亡、肿瘤发生、细胞骨架 …
潜在热门靶点PAK4梳理 - 健康界
2020年12月3日 · p21 活化激酶4 (p21-activated kinase 4，PAK4) 是丝氨酸/苏氨酸蛋白激酶，参与体内多条信号通路，影响肿瘤细胞的增殖、存活、侵袭转移及凋亡，对肿瘤的发生发展起着重 …