4 天之前 · Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser473 of mouse Akt. Akt, also referred to as PKB or Rac, plays a critical role in controlling cell survival and apoptosis (1-3).

3 天之前 · Phospho-Akt (Ser473) Antibody (IHC Specific) detects Akt1 only when phosphorylated at serine 473, and Akt2 and Akt3 only when phosphorylated at equivalent sites. This antibody was developed for and is recommended for immunohistochemical application only.

2019年1月31日 · Our analysis revealed that the pAKT pathway activation was associated with luminal A BC while the p-mTOR pathway activation was more associated with luminal B BC (Kruskal–Wallis test p < 10 −10)....

2015年3月25日 · We propose that pAkt is a potential molecular marker for prediction of breast cancer's behavior. We also propose the possible use of ICC analysis on imprint smears or in fine-needle aspiration material to evaluate pAkt as prognostic factor in breast carcinoma.

2015年4月1日 · Diagnostic tumor biopsies from 193 sequential patients with stage III/IV ADC were prospectively studied for HER2 expression by immunohistochemistry (IHC). Cases with IHC scores 2+ or 3+ were analyzed by HER2 chromogenic in situ hybridization (CISH), and sequencing of HER2 exons 20 and 23.

2017年8月29日 · One of the crucial mechanisms underlying hormonal therapy resistance is the collateral activation of the phosphatidylinositol-3 kinase (PI3K)/AKT pathway. We explored whether PI3K inhibitors, buparlisib and alpelisib, enhance the efficacy of tamoxifen against ER-positive BC cells.

Evaluations of EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry (IHC) were carried out on all 45 tissue samples and their correlations with response to trastuzumab, incidence of central nervous system (CNS) metastases, time to progression (TTP), overall survival from diagnosis of breast cancer (OS1), from diagnosis of metastatic ...

2014年10月17日 · Levels of pAkt S473 and pAkt T308, as determined by IHC, were examined for association with overall survival using Cox’s proportional hazard model (Table 3). In multivariate analysis, pAkt S473 level, tumor size, alcohol consumption, age and patients’ HPV status had significant effects on overall survival (P = 0.005, 0.005, 0.021, 0.007 and ...

2 天之前 · Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser473 of human Akt. Akt, also referred to as PKB or Rac, plays a critical role in controlling cell survival and apoptosis (1-3).