Panx-1 is closely related to the development of tumor, but the exact mechanism of Panx-1 in cancer is still not clear. We speculate that Panx-1 may have protective or destructive …

In the last decade, pannexin (Panx) channels have been identified as key mediators of extracellular ATP release. The Panx family consists of 3 members, namely Panx1, Panx2 and …

Pannexin 1 (PANX1) channel is a critical ATP-releasing pathway that modulates tumor immunity, progression, and prognosis. However, the roles of PANX1 in different cancers remain unclear. …

2024年11月1日 · Pannexins (PANXs) are expressed by mammalian immune and nonimmune cells and promote the export of many <1-kDa small molecules, at steady-state or in response …

2024年10月1日 · In vitro cell function and in vivo tumorigenesis experiments showed that PANX2 promoted CRC cell proliferation, clone formation, migration and tumorigenesis in vivo. WB …

2024年8月15日 · PANX1 protein expression and distribution were evaluated by immunohistochemistry on primary tumor tissue and non-tumor colonic mucosa from colon …

Pannexin1 (Panx-1) is a gap junction channel protein that mediates the release of intracellular ATP during autophagy, and thus plays an important role in tumor cell apoptosis and chemo …

2009年9月14日 · Pannexin2 (Panx2) is a member of the novel gap junction protein family, Panxs, and it has been proposed as a brain-specific protein. Recently, gene array analysis showed an …

Further, PANX1 is activated when cancer cells are subjected to deformation as they travel along the microvasculature, which contributes to cancer metastasis . Moreover, focused ultrasound …

Pannexin 1 (PANX1) channel is a critical ATP-releasing pathway that modulates tumor immunity, progression, and prognosis. However, the roles of PANX1 in different cancers remain unclear. …