Panx-1 is closely related to the development of tumor, but the exact mechanism of Panx-1 in cancer is still not clear. We speculate that Panx-1 may have protective or destructive properties in different types of tumors. In addition, the role of Panx-1 in cancer may also be dependent on tumor stage and severity. In Furlow's study, it was shown ...

In the last decade, pannexin (Panx) channels have been identified as key mediators of extracellular ATP release. The Panx family consists of 3 members, namely Panx1, Panx2 and Panx3 [18]. Among those, Panx1 has yet been most extensively studied.

Pannexin 1 (PANX1) channel is a critical ATP-releasing pathway that modulates tumor immunity, progression, and prognosis. However, the roles of PANX1 in different cancers remain unclear. We analyzed the expression of PANX1 in human pan-cancer in …

2024年11月1日 · Pannexins (PANXs) are expressed by mammalian immune and nonimmune cells and promote the export of many <1-kDa small molecules, at steady-state or in response to disease. In mice and humans, PANX1 is a crucial regulator of lung adaptive immunity, controlling conventional and regulatory CD4 + T cell immune responses to lung allergens.

2024年10月1日 · In vitro cell function and in vivo tumorigenesis experiments showed that PANX2 promoted CRC cell proliferation, clone formation, migration and tumorigenesis in vivo. WB result revealed that PANX2 may lead to resistance to 5-Fu in CRC by affecting the PI3K - …

2024年8月15日 · PANX1 protein expression and distribution were evaluated by immunohistochemistry on primary tumor tissue and non-tumor colonic mucosa from colon cancer patients. PANX1 inhibitors (probenecid or 10 Panx) were used to …

Pannexin1 (Panx-1) is a gap junction channel protein that mediates the release of intracellular ATP during autophagy, and thus plays an important role in tumor cell apoptosis and chemo-resistance. However, the role of Panx-1 in cisplatin-resistance of testicular cancer cells …

2009年9月14日 · Pannexin2 (Panx2) is a member of the novel gap junction protein family, Panxs, and it has been proposed as a brain-specific protein. Recently, gene array analysis showed an overall...

Further, PANX1 is activated when cancer cells are subjected to deformation as they travel along the microvasculature, which contributes to cancer metastasis . Moreover, focused ultrasound (FUS) can stimulate ER-localized mechanosensitive PANX1 and result in the release of Ca 2+ from the ER in invasive cancer cells [ 42 ].

Pannexin 1 (PANX1) channel is a critical ATP-releasing pathway that modulates tumor immunity, progression, and prognosis. However, the roles of PANX1 in different cancers remain unclear. We analyzed the expression of PANX1 in human pan-cancer in …