2025年1月24日 · We work on uncovering the physical principles that underlie how proteins and nucleic acids are organized in space and time within cells. This work has a strong focus on macromolecular phase transitions. We also work on uncovering sequence-ensemble-function relationships of intrinsically disordered proteins (IDPs).

5 天之前 · A high-avidity, thermostable, and low-cost synthetic capture for ultrasensitive detection and quantification of viral antigens and aerosols. ACS Sensors, 9: 3096-3104.

Rohit Pappu's research focuses on the form, functions and phase transitions of intrinsically disordered proteins and multivalent macromolecules. His work, which is driven by a combination of polymer physics theories, computational biophysics, machine learning and biochemical experiments in vitro and in living cells, is aimed at understanding ...

Rohit Pappu is an Indian-born computational and molecular biophysicist. He is the Gene K. Beare Distinguished Professor of Engineering and the director of the Center for Biomolecular Condensates (CBC) at Washington University in St. Louis .

RV Pappu, R Srinivasan, GD Rose. Proceedings of the National Academy of Sciences 97 (23), 12565-12570, 2000. 363: 2000:

Research in the Pappu lab is focused on intrinsically disordered proteomes. Multiscale modeling approaches and biophysical tools are used in this research. Eukaryotic proteomes are enriched in proteins that function despite being unable to fold autonomously into well defined three-dimensional structures.

CIDER is a webserver being developed by the Pappu Lab for calculating parameters relating to disordered protein sequences. Specifically, this will calculate various parameters which help translate primary sequence information into better understanding how the unstructured ensemble might behave, as well as annotating your sequence on the diagram ...

H. R. Pappu Tobacco rattle virus (TRV), an important pathogen of potato, tobacco and ornamental bulbs, consists a segmented, positive sense RNA genome (RNA1, 6.79 kb and RNA2, 3.86 kb).

2023年7月26日 · Here, we review the key concepts of phase transitions of aqueous solutions of associative biomacromolecules, specifically proteins that include folded domains and intrinsically disordered regions. The phase transitions of these systems come under the rubric of coupled associative and segregative transitions.

Semantic Scholar profile for R. Pappu, with 369 highly influential citations and 85 scientific research papers.