Par14 (eukaryotic homolog of parvulin, EHPF) is a member of the parvulin family of peptidyl-prolyl-cis/trans-isomerases (PPIases) in humans, which possesses prolyl isomerase activity. [1]

Although parvulin (Par14/eukaryotic parvulin homolog), a peptidyl-prolyl cis-trans isomerase, is found associated with the preribosomal ribonucleoprotein (pre-rRNP) complexes, its roles in ribosome biogenesis remain undetermined. In this study, we ...

Results: Par14 markedly enhanced insulin signaling by associating with IRS-1, and hepatic overexpression of Par14 normalized hyperglycemia in diabetic mice. Conclusion: Par14 exhibits an insulin-sensitizing effect. Significance: This is the first report showing the roles of Par14 in metabolism and signal transduction.

We report that Par14, one isoform of the prolyl isomerases homologous to Pin1, is a critical regulator of AR transcriptional activity and is essential for PCa cell growth. Results. Par14 was shown to be overexpressed in PCa, based on analyses of deposited data.

2024年12月25日 · PARP14 (Poly (ADP-Ribose) Polymerase Family Member 14) is a Protein Coding gene. Diseases associated with PARP14 include Diphtheria and Tfe3-Rearranged Renal Cell Carcinoma. Among its related pathways are Translation of …

2019年3月5日 · The parvulin 14 (Par14) and parvulin 17 (Par17) proteins, which are both encoded by the PIN4 gene, play roles in protein folding, chromatin remodeling, DNA binding, ribosome biogenesis, and cell cycle progression.

Par14 was shown to directly associate with AR in nuclei via its DNA-binding domain and augment AR transcriptional activity. Conclusion: Thus, Par14 plays a critical role in PCa progression, and its enhancing effects on AR signaling are likely to be …

2015年2月3日 · Par14, a member of the parvulin family of peptidyl-prolyl cis-trans isomerases that is involved in rRNA processing, microtubule formation and the glucose metabolism and has been suggested to play a role in chromatin remodeling on basis …

2020年7月28日 · Par14 is involved in biogenesis of ribonucleoprotein (RNP)-complexes, RNA processing and DNA repair. Its elongated isoform Par17 participates in protein transport/translocation and in cytoskeleton organization.

In addition to Pin1, the human genome only contains a single other parvulin locus encoding two protein species—Par14 and Par17. Much less is known about these enzymes although their sequences are highly conserved in all metazoans.