Paradoxical psoriasis is a drug side effect that results in the formation of red, scaly, psoriasiform plaques on the skin due to treatment with tumour necrosis factor alpha (TNFα) inhibitors. TNF α inhibitors are used to treat autoimmune conditions such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis.

2018年11月1日 · Some biologic therapies favor granulomatous reactions. While most of the paradoxical reactions reported have been associated with the use of TNF-α inhibitors, cases associated with more recently introduced biologic therapies —such as ustekinumab, secukinumab, and ixekizumab—are increasingly common.

The definition of paradoxical psoriasis (PP) encompasses 2 main scenarios, namely, (i) new-onset psoriasis in patients treated for a different disease and (ii) worsening as well as phenotypical change of pre-existing psoriasis (Murphy et al., 2022).

Here, we present a case of paradoxical skin reactions – pyoderma gangrenosum (PG) and eczema – induced by biologic therapy. The case was successfully and eventually treated with baricitinib. PG is a rare inflammatory disease characterised by painful and necrotic ulcerations containing neutrophils.

肿瘤坏死因子α抑制剂（tumor necrosis factor-α inhibitor，TNFi）在类风湿性关节炎、强直性脊柱炎、克罗恩病、银屑病等多种炎症性疾病中有一定疗效，其常见皮肤相关的不良反应有局部注射反应、皮肤感染、皮肤肿瘤、免疫介导的皮肤反应等，其中免疫介导的皮肤反应包括皮肤狼疮样反应、斑秃、白癜风、原有银屑病加重或新发银屑病等。 此类与TNFi等生物制剂相关的银屑病也叫矛盾性银屑病（paradoxical psoriasis，PP）。

This cohort study examines which biologic drug classes and factors are associated with risk of paradoxical eczema in patients with psoriasis treated with

Some biologic therapies favor granulomatous reactions. While most of the paradoxical reactions reported have been associated with the use of TNF-α inhibitors, cases associated with more recently introduced biologic therapies -such as ustekinumab, secukinumab, and ixekizumab- are increasingly common.

2024年3月19日 · Paradoxical psoriasis (PP) may be defined as the unexpected occurrence or worsening of psoriasiform skin lesions in patients undergoing treatment with biologics or small molecules (Murphy et al, 2022).

2023年12月1日 · During the anti -TNF-α treatment of classical idiopathic psoriasis, a small portion of patients develop new psoriasiform lesions. This contradictory phenomenon was named paradoxical psoriasis which resembles idiopathic psoriasis clinically but presents overlapped histological patterns and distinct immunological processes.

Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory …