ccdB基因位于大肠杆菌的 F质粒 上，是被ccd操纵子编码的毒性-抗毒性系统的一部分，确保含F质粒的细胞分裂后F质粒仍存在（分裂后含F质粒的细胞才能存活）。

2012年9月28日 · Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase inhibitor encoded by the ccd system of plasmid F, and Kid, a site-specific endoribonuclease encoded by the parD system of plasmid R1.

The CcdA/CcdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin).

结构数据揭示了两种模型 TA 毒素 CcdB（一种由质粒 F 的 ccd 系统编码的 DNA 促旋酶抑制剂）和 Kid（一种由质粒 R1 的 parD 系统编码的位点特异性核糖核酸内切酶）之间的惊人相似之处。

2019年7月8日 · It is found that ParDE I is a plasmid stability and stress response module that increases tolerance of aminoglycoside, quinolone and β-lactam antibiotics in E. coli by ~100–1,000-fold, and thus to...

Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase inhibitor encoded by the ccd system of plasmid F, and Kid, a site-specific endoribonuclease encoded by the parD system of plasmid R1.

2012年10月19日 · In addition to focus on the molecular mechanism of poisoning of DNA-gyrase by CcdB F and ParE RK2 as well as structural data, we describe here the different systems encoding CcdB-like and ParE-like toxins and highlight the specific features of those systems in terms of antitoxin structure and properties, autoregulation, biological functions ...

2012年9月28日 · Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase inhibitor encoded by the ccd system of plasmid F, and Kid, a site …

Totest whether thewild-type ParD system can complement the ham22 mutation, an OV2 strain containing two multicopy, compatible plasmids, The Kis and CedA proteins of the ParD and Ccd systems pULB2007 (ham22 ccdB +) and pET80 (kis + …

2005年5月1日 · CcdB stabilizes the covalently linked enzyme–DNA intermediate and thereby stalls E. coli and T7 RNA polymerases in in vitro transcription reactions. Blockage of the polymerases was reversed by ...