PARP1 - Wikipedia
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly [ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] . It …
The multifaceted roles of PARP1 in DNA repair and chromatin
2017年7月5日 · PARP1 is an abundant nuclear protein that post-translationally attaches a negatively charged polymer termed poly (ADP-ribose) (PAR) to itself and to multiple target …
PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs
Poly (ADP-ribose) polymerase 1 (PARP1), the best-studied isoform of the nuclear enzyme PARP family, plays a pivotal role in cellular biological processes, such as DNA repair, gene …
PARP1 Gene - GeneCards | PARP1 Protein | PARP1 Antibody
2024年12月25日 · PARP1 (Poly (ADP-Ribose) Polymerase 1) is a Protein Coding gene. Diseases associated with PARP1 include Diphtheria and Fallopian Tube Carcinoma. Among its related …
Transcriptional regulation mechanism of PARP1 and its …
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic integrity, this nuclear …
PARP1: Structural insights and pharmacological targets for
Poly(ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base …
The Enigmatic Function of PARP1: From PARylation Activity to …
PARP1 was first described by its role in the repair of alkylating agent-induced DNA base damages and also single strand breaks (SSBs). PARP1 is involved in base excision repair (BER) via …
Poly(ADP-ribose) polymerase inhibition: past, present and future
2020年9月3日 · Poly (ADP-ribose) polymerase 1 (PARP1) cleaves NAD + to ADP-ribose and nicotinamide, and covalently attaches ADP-ribose to an acceptor protein. Additional NAD + …
Current Advances in PARP1-Targeted Theranostics - PubMed
Poly (ADP-ribose) polymerase 1 (PARP1) plays critical roles in DNA repair, chromatin regulation, and cellular equilibrium, positioning it as a pivotal target for therapeutic interventions in cancer …
The complex universe of inactive PARP1: Trends in Genetics - Cell …
2024年9月20日 · Poly (ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family, which modifies targets through ADP-ribosylation and plays key roles in a variety of …