The mouse PASI scoring system, based on the human psoriasis scoring system, could reproducibly differentiate the severity of plaque psoriasis lesions based on three …

The PASI clinical scoring system was used to assess the inflammatory status of the mice dorsal skin for all the 8 days. It included the visual examination of the following three parameters: …

2021年3月1日 · The Psoriasis Area and Severity Index (PASI), used in the clinical psoriasis evaluation (Mattei, Corey, & Kimball, 2014), which consists of measurements for erythema, …

Our standard in vivo readouts are mouse weight, ear and skin thickness, and Psoriasis Area and Severity Index (PASI) scoring (skin color, thickness, and scaling). At the end of the study, we …

2021年1月28日 · In this study, we optimized the IMQ-induced mouse model of psoriasis and developed a repeatable model with proper severity and stable pathogenesis for the …

百奥赛图构建了一系列IMQ诱导的银屑病小鼠模型，可用于银屑病相关药物的临床前研究和药效评价。 IMQ成功诱导小鼠产生银屑病。 (A)IMQ涂抹4天后的小鼠背部皮肤病损程度。 (B-D)背部 …

Charles River has characterized a clinically relevant psoriasis model in mice through the topical application of 5% imiquimod (IMQ) cream. This imiquimod-induced psoriasis models human …

2022年1月1日 · The severity of mouse psoriatic lesions was assessed by PASI. The indices included infiltration (skin thickness), scales (desquamation), and erythema. Each index was …

2019年2月1日 · Mice pre-treated 3 days with PSORI-CM02 significantly alleviated skin inflammation, as reduced in PASI score and classic psoriatic characteristics in pathological …

2009年5月1日 · Here we demonstrate that IMQ-treated mouse skin closely resembles human plaque-type psoriasis with respect to erythema, skin thickening, scaling, epidermal alterations …