GPI 锚是一种在许多血细胞上发现的糖脂，用于将蛋白质锚定到细胞表面。 阵发性睡眠性血红蛋白尿症是一种获得性血液病，已被证明是由该基因突变引起的。 交替剪接变体已被表征。 一个相关的假基因位于 12 号染色体上。 [RefSeq 提供，2010 年 6 月] This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor.

多聚免疫球蛋白受体 (polymeric immunoglobulin receptor,pIgR)是介导多聚免疫球蛋白 (包括pIgA和pIgM)转运通过粘膜上皮细胞的一种Ⅰ型跨膜糖蛋白.pIgR在上皮细胞的基底... 多聚免疫球蛋白受体 (pIgR)属于I型跨膜糖蛋白,可以与多聚免疫球蛋白A和多聚免疫球蛋白M特异性结合,通过穿胞转运,将它们从上皮细胞基底侧膜转运到顶膜,并最终分泌到外分... 上皮细胞通过抗原与pIgA交联的mIgA和IgG的转运〔英〕/CharlotteS…//JImmunol.-1994,152 (1).-72～75传统的免疫球蛋白 …

Per-Arnt-Sim Kinase (PASK) is an evolutionarily-conserved nutrient-responsive protein kinase that regulates lipid and glucose metabolism, mitochondrial respiration, phosphorylation, and gene expression. Recent data suggests that mammalian PAS kinase ...

polylinker derived amino acids pASK-IBA and pEXPR-IBA vectors offer a general cloning strategy via Type IIS restriction enzymes, BsaI or Eco31I (NEB, MBI Fermentas). They allow the precise fusion of the structural gene with the vector encoded functional elements

2015年2月27日 · Phosphatidylinositol glycan biosynthesis class A protein (PIGA) is one of the enzymes involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchor proteins, which function as enzymes, adhesion molecules, complement regulators and co-receptors in signal transduction pathways.

Objective: To define the phenotypic spectrum of phosphatidylinositol glycan class A protein (PIGA)-related congenital disorder of glycosylation (PIGA-CDG) and evaluate genotype-phenotype correlations. Methods: Our cohort encompasses 40 affected males with a pathogenic PIGA variant. We performed a detailed phenotypic assessment, and in addition ...

2001年10月1日 · Patients with paroxysmal nocturnal hemoglobinuria (PNH) have blood cells deficient in glycosyl phosphatidylinositol (GPI)–linked proteins owing to a somatic mutation in the X-linked PIGA gene.

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Quantitative phosphoproteomic analysis of T cell …

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PAS kinase (PASK) is a nutrient sensor proposed as a regulator of glucose metabolism and cellular energy. The role of PASK might be similar to other known metabolic sensors, such as AMP-activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR).