ATLANTA-- Inhibitex, Inc. (NASDAQ: INHX) announced today that a poster presentation describing preclinical data on INX-189, the lead compound from its HCV nucleotide polymerase inhibitor program, will be presented by Dr. Joseph M. Patti, Chief Scientific Officer and Senior Vice President of R&D, at the 60th Annual Meeting of the American ...

INX-08189 is an aryl-phosphoramidate of 6-O-methyl-2′-C-methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10 ± 6 nM against hepatitis C...

2011年3月1日 · Semantic Scholar extracted view of "460 A STUDY OF THE SAFETY AND PHARMACOKINETICS OF SINGLE ASCENDING ORAL DOSES OF INX-08189, A NUCLEOTIDE POLYMERASE INHIBITOR, IN HEALTHY SUBJECTS" by J. Patti et al.

Patti, J., Matson, M., Boehlecke, B., Barry, A., Wenzel, E., Pentikis, H., … Henson, G. (2011). 460 A STUDY OF THE SAFETY AND PHARMACOKINETICS OF SINGLE ASCENDING ORAL DOSES OF INX-08189, A NUCLEOTIDE POLYMERASE INHIBITOR, IN HEALTHY SUBJECTS. Journal of Hepatology, 54, S187. doi:10.1016/s0168 …

2013年6月1日 · INX-08189, a phosphoramidate prodrug of 6-O-methyl-2′-C-methyl guanosine, is a potent inhibitor of Hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties

PattiJefferson, FAPA Member

2010年8月15日 · The potency of the lead compound INX-08189 was shown to be consistent with intracellular 2'-C-methyl guanosine triphosphate levels in primary human hepatocytes. The separated diastereomers of INX-08189 were shown to have similar activity in the replicon assay and were also shown to be similar substrates for enzyme processing.

INX-08189 is an aryl-phosphoramidate of 6-O-methyl-2'-C-methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10±6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral replication was rapid, with a 50% effective concentration (E …

365 Bright Ideas for Marketing Your Indie Books: An Author's Practical Guide to Daily Marketing Jefferson, Patti Published byPJ Inx Press, 2018 ISBN 10: 0999840401ISBN 13: 9780999840405 Seller: SecondSale, Montgomery, IL, U.S.A. Seller Rating: Contact seller Book Used - SoftcoverCondition: Good US$ 21.96 Convert currency Free shipping Within U.S.A.

Patti Brassard Jefferson is an award-winning illustrator and author of children’s books as well as non-fiction. She is currently the president of the Florida Authors and Publishers Association and CEO of PJ Inx Press.