
Acetylation of PAX7 controls muscle stem cell self-renewal and ... - Nature
2021年5月31日 · Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of …
Pax7 and myogenic progression in skeletal muscle satellite cells
2006年5月1日 · Skeletal muscle growth and regeneration are attributed to satellite cells - muscle stem cells resident beneath the basal lamina that surrounds each myofibre. Quiescent satellite …
Pax7+ Satellite Cells in Human Skeletal Muscle After Exercise: A ...
Background: Skeletal muscle has extraordinary regenerative capabilities against challenge, mainly owing to its resident muscle stem cells, commonly identified by Pax7 +, which …
PAX7, a Key for Myogenesis Modulation in Muscular Dystrophies …
Overall, Pax7 plays a critical role in muscle development, and contributes to skeletal muscle repair through its regenerative function. In terms of signaling pathways, research on Pax7 …
Pax7 and myogenic progression in skeletal muscle satellite cells
2006年5月1日 · Here we show that Pax7 is able to drive transcription in quiescent and activated satellite cells, and continues to do so in those cells that subsequently cease proliferation and …
Regenerating human skeletal muscle forms an emerging niche in …
2023年11月2日 · We used spatial RNA sequencing to identify key factors driving emerging human niche formation between ACTC1 + myofibres and PAX7 + SMPCs in vivo. This revealed that …
MLL1 is required for PAX7 expression and satellite cell self
2019年9月18日 · PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while …
Pax7+ Satellite Cells in Human Skeletal Muscle After Exercise: A ...
Pax7 + cells are myogenic stem cells contributing to muscle repair by a quick fusion of nuclei into the cytoplasm of myofibers and plays a key role in muscle plasticity against acute exercise …
PAX7 - Wikipedia
Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. It can bind to DNA as an heterodimer with PAX3. Also interacts …
Pax7 is critical for the normal function of satellite cells in adult ...
2013年9月24日 · Here, we demonstrate that Pax7 is an absolute requirement for satellite cell function in adult skeletal muscle. Following Pax7 deletion, satellite cells and myoblasts exhibit …
The regenerative potential of Pax3/Pax7 on skeletal muscle injury
The mechanism of action of Pax3/Pax7 for skeletal muscle stem cells is divided into two mechanisms; cellular and molecular mechanisms. A Cellularly, the mechanism consists of six …
3D Mechanical Confinement Directs Muscle Stem Cell Fate and …
2025年3月4日 · The Pax7 transcription factor is the characteristic marker of MuSCs in adult skeletal muscle, whereas activated and differentiating MuSCs gradually lose Pax7 expression. …
Pax7 is back | Skeletal Muscle | Full Text - BioMed Central
2014年12月14日 · Two compounding factors are likely responsible for the different outcomes of Pax7 deletion on muscle repair: (1) limitations in Cre lox technology, and (2) the insatiable …
Pax7 remodels the chromatin landscape in skeletal muscle stem …
Our studies provide new insights into the epigenetic landscape of skeletal muscle stem cells and precursors and the role of Pax7 in satellite cell specification. A major unexplored area in …
Acetylation of PAX7 controls muscle stem cell self-renewal and ...
2021年5月31日 · Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of …
PAX7 Gene: Function, Role in Muscle Development, and
PAX7, a member of the paired box (PAX) family of transcription factors, plays a pivotal role in muscle development and regeneration. It acts as a master regulator, controlling the …
PAX7, a Key for Myogenesis Modulation in Muscular Dystrophies …
2023年8月22日 · Overall, Pax7 plays a critical role in muscle development, and contributes to skeletal muscle repair through its regenerative function. In terms of signaling pathways, …
Pax7-expressing satellite cells are indispensable for adult …
2011年9月1日 · Given the recently revised role of Pax7 in adult myogenesis, as well as reports that non-satellite cells can contribute to muscle growth and regeneration, this model provides …
Pax7 is critical for the normal function of satellite cells in adult ...
Here, we demonstrate that Pax7 is an absolute requirement for satellite cell function in adult skeletal muscle. Following Pax7 deletion, satellite cells and myoblasts exhibit cell-cycle arrest …
Marking the tempo for myogenesis: Pax7 and the regulation of muscle …
Here we will critically review key findings suggesting that Pax7 may play a dual role by promoting resident muscle progenitors to commit to the skeletal muscle lineage while preventing terminal …