2021年5月31日 · Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of …

2006年5月1日 · Skeletal muscle growth and regeneration are attributed to satellite cells - muscle stem cells resident beneath the basal lamina that surrounds each myofibre. Quiescent satellite …

Background: Skeletal muscle has extraordinary regenerative capabilities against challenge, mainly owing to its resident muscle stem cells, commonly identified by Pax7 +, which …

Overall, Pax7 plays a critical role in muscle development, and contributes to skeletal muscle repair through its regenerative function. In terms of signaling pathways, research on Pax7 …

2006年5月1日 · Here we show that Pax7 is able to drive transcription in quiescent and activated satellite cells, and continues to do so in those cells that subsequently cease proliferation and …

2023年11月2日 · We used spatial RNA sequencing to identify key factors driving emerging human niche formation between ACTC1 + myofibres and PAX7 + SMPCs in vivo. This revealed that …

2019年9月18日 · PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while …

Pax7 + cells are myogenic stem cells contributing to muscle repair by a quick fusion of nuclei into the cytoplasm of myofibers and plays a key role in muscle plasticity against acute exercise …

Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. It can bind to DNA as an heterodimer with PAX3. Also interacts …

2013年9月24日 · Here, we demonstrate that Pax7 is an absolute requirement for satellite cell function in adult skeletal muscle. Following Pax7 deletion, satellite cells and myoblasts exhibit …

The mechanism of action of Pax3/Pax7 for skeletal muscle stem cells is divided into two mechanisms; cellular and molecular mechanisms. A Cellularly, the mechanism consists of six …

2025年3月4日 · The Pax7 transcription factor is the characteristic marker of MuSCs in adult skeletal muscle, whereas activated and differentiating MuSCs gradually lose Pax7 expression. …

2014年12月14日 · Two compounding factors are likely responsible for the different outcomes of Pax7 deletion on muscle repair: (1) limitations in Cre lox technology, and (2) the insatiable …

Our studies provide new insights into the epigenetic landscape of skeletal muscle stem cells and precursors and the role of Pax7 in satellite cell specification. A major unexplored area in …

2021年5月31日 · Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of …

PAX7, a member of the paired box (PAX) family of transcription factors, plays a pivotal role in muscle development and regeneration. It acts as a master regulator, controlling the …

2023年8月22日 · Overall, Pax7 plays a critical role in muscle development, and contributes to skeletal muscle repair through its regenerative function. In terms of signaling pathways, …

2011年9月1日 · Given the recently revised role of Pax7 in adult myogenesis, as well as reports that non-satellite cells can contribute to muscle growth and regeneration, this model provides …

Here, we demonstrate that Pax7 is an absolute requirement for satellite cell function in adult skeletal muscle. Following Pax7 deletion, satellite cells and myoblasts exhibit cell-cycle arrest …

Here we will critically review key findings suggesting that Pax7 may play a dual role by promoting resident muscle progenitors to commit to the skeletal muscle lineage while preventing terminal …