2011年4月12日 · Here we demonstrate that the bone marrow X-linked (BMX) nonreceptor tyrosine kinase activates STAT3 signaling to maintain self-renewal and tumorigenic potential of GSCs. BMX is differentially expressed in GSCs relative to …

These data indicate that ibrutinib is effective at inhibiting the growth of most GSC subtypes. We further analyzed the expression of total BMX and the phosphorylated active BMX (pBMX-Y40) in human GBM specimens through IHC staining to predict the fractions of GBM patients that may benefit from ibrutinib therapy.

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