Checkpoint kinase1 (CHK1) is an important biomarker in breast …
Checkpoint kinase1 (CHK1), which is a key component of DNA-damage-activated checkpoint signalling response, may have a role in breast cancer (BC) pathogenesis and influence …
Lack of PTEN sequesters CHK1 and initiates genetic instability
2005年2月1日 · Here we demonstrate that CHK1, a critical regulator of chromosomal stability, is impaired in cells lacking PTEN due to AKT-mediated phosphorylation at serine 280, which …
Inhibition of BAD-Ser99 phosphorylation synergizes with PARP
2022年6月20日 · Loss of Phosphatase and tensin homolog (PTEN) function is positively associated with endometrial carcinoma (EC) progression [1]. PTEN is a tumor suppressor …
A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a …
2013年3月4日 · In tumor specimens from 187 patients with non-small-cell lung cancer, total CHK1 and RRM1 in situ protein levels were significantly (p = 0.003) and inversely correlated. We …
Chk1 phosphorylated at serine345 is a predictor of early local ...
Pre-clinically, radio-sensitisation by VE-821 or V158411 was observed in both MCF-7 and MDA-MB-231 cells and was more pronounced in MCF-7 cells. We conclude that pChk1 is a …
PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in …
Loss of PTEN impairs CHK1-mediated checkpoint activation due to cytoplasmic sequestration of ubiquitinated CHK1. Here, we provide evidence that another consequence of reduced CHK1 …
Pten−/− cells display a partially defective checkpoint in response to ionizing radiation (IR). The checkpoint defect was traced to the ability of AKT to phosphorylate CHK1 at serine 280, since …
Nuclear pCHK1 as a potential biomarker of increased sensitivity to …
Using an advanced multispectral imaging system in subsequent cell line‐derived xenograft specimens, we showed a trend between nuclear phosphorylated CHK1 (pCHK1) staining and …
Chk1 phosphorylated at serine345 is a predictor of early local ...
2016年2月1日 · In the current study, we have comprehensively investigated the expression of a panel of DNA repair factors involved in the DDR: DNA damage signalling (ATM, ATR, total …
Lack of PTEN sequesters CHK1 and initiates genetic instability
2004年5月26日 · Here we demonstrate that CHK1, a critical regulator of chromosomal stability, is impaired in cells lacking PTEN due to AKT-mediated phosphorylation at serine 280, which …