2023年12月25日 · 抗PCNA抗体 是抗增殖细胞核抗原抗体，抗PCNA抗体阳性指体内存在针对细胞核中抗原物质所产生的一种自身抗体，与一些疾病有关，如 系统性红斑狼疮 和肿瘤细胞，抗PCNA抗体可以作为细胞增殖状态的指标。 由Miyachi等于1978年在SLE（系统性红斑狼疮）患者的血清中首次发现抗增殖型细胞核抗原抗体并命名，抗增殖型细胞核抗原抗体是系统性红斑狼疮的特异性抗体，可作为系统性红斑狼疮的标记性抗体，若检测阳性，则有可能患有系统性红斑狼 …

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin ...

Proliferating cell nuclear antigen (PCNA) is an evolutionarily well-conserved protein found in all eukaryotic species as well as in Archaea. PCNA was first shown to act as a processivity factor of DNA polymerase δ, which is required for DNA synthesis during replication (Tan et al., 1986; Bravo et al., 1987; Prelich et al., 1987).

Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA polymerases and other DNA editing enzymes. It also interacts with regulatory proteins through a sequence motif known as PCNA Interacting Protein box (PIP-box).

PCNA exerts a tripartite function by operating as (1) a sliding clamp during DNA synthesis, (2) a polymerase switch factor and (3) a recruitment factor. Most of its functions are mediated by its interactions with various proteins involved in DNA synthesis, repair and recombination as well as in regulation of the cell cycle and chromatid cohesion.

24036-1-AP targets PCNA in WB, IHC, IF/ICC, IF-P, IP, RIP, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

2024年12月25日 · PCNA (Proliferating Cell Nuclear Antigen) is a Protein Coding gene. Diseases associated with PCNA include Ataxia-Telangiectasia-Like Disorder 2 and Actinic Keratosis. Among its related pathways are Base excision repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.

2024年6月1日 · Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp that plays multiple roles during chromosome duplication and damaged DNA repair. After the completion of its function, PCNA is unloaded from DNA by a replication factor C-like complex (RLC) called ATAD5-RLC.

摘要 增殖细胞核抗原(pcna)是真核生物复制复合体的核心成分,具有特殊的环状三级结构．作为真核细胞dna聚合酶δ的推动因子,与不同复制相关蛋白结合,协调dna复制过程．同时pcna还作为功能转换因子,通过不同调控方式与多种细...

2023年12月28日 · 戴安生物最新开发出来的pcna单克隆抗体，精选人pcna蛋白序列设计抗原，可用于人、小鼠、大鼠样本的wb检测内参。 另外，抗体效价也非常高，在WB实验中推荐稀释比为1:2,000~1:5,000。