Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5 ′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium - and calmodulin -dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1-PDE11).

pde1有3种同功酶：pde1a、1b和1c，分别由不同的基因编码。 PDE1的 催化活性 是通过两个CaM结合区域来调控的，然而每种同功酶都有其被激活的独特Ca阈值。

PDE1：分布于平滑肌、心脏、肺、神经系统、生殖系统等;其作用包括调节平滑肌细胞收缩增殖、调节精子活动、调节免疫细胞功能等； PDE2：分布于肾上腺、神经系统、平滑肌、巨噬细胞、内皮细胞等;其功能包括调节 cGMP 和 cAMP之间的相互作用、调节肾上腺的分泌作用、调节神经系统活动、心肌钙离子通道活性等； PDE3：分布于心脏、血管平滑肌、血小板、肾、肝、免疫细胞等;其作用包括:调节心肌收缩力、血小板聚集、血管平滑肌收缩、肾素释放及胰岛素信号转导 …

In the past decades, numerous PDE1 inhibitors with structural diversities have been developed and patented by pharmaceutical companies, providing drug candidates for exploring novel disease indications of PDE1. Area covered: This review aims to provide an overview of PDE1 inhibitors reported in patents from 2008 to present.

Cyclic nucleotide phosphodiesterases (PDEs) are superfamily of enzymes that regulate the spatial and temporal relationship of second messenger signaling in the cellular system. Among the 11 different families of PDEs, phosphodiesterase 1 (PDE1) sub-family of enzymes hydrolyze both 3',5'-cyclic adeno …

2021年10月1日 · PDE1 is a dual substrate (cAMP and cGMP) diesterase and a promising target for the treatment of heart disease, cancer, neurological disorder and other endocrine abnormalities.

磷酸二酯酶1 ， pde1 ，ec 3.1.4.1，系统名称寡核苷酸5 ' -核苷酸氢化素酶）是一种磷酸二酯酶，也称为钙- 钙二糖蛋白依赖蛋白依赖性磷酸二酯酶。它是磷酸二酯酶的11个家族之一（pde1-pde11）。磷酸二酯酶1具有三种亚型pde1a...

PDE1 is a group of enzymes that require both calcium and calmodulin for their activity. They are encoded by three genes in humans and are involved in the degradation of cyclic nucleotides, specifically cGMP and cAMP. The exact function of PDE1 in the airways smooth muscle is currently unknown.

环核苷酸磷酸二酯酶 (PDE) 通过将 cAMP 和/或 cGMP 水解成各自的核苷 5-主要单磷酸来调节细胞内环核苷酸浓度，从而在信号转导中发挥作用。 PDE1 家族的成员，例如 PDE1A，是 CA (2+) /钙调蛋白 (参见 CALM1；MIM 114180) 依赖性 PDE (CaM-PDE) ，在 CA (2+) 存在的情况下被钙调蛋白激活 (Michibata 等 al., 2001 [PubMed 11342109]；Fidock 等人，2002 [PubMed 11747989]) . [OMIM 提供，2009 年 10 月]

As a Class 1 phosphodiesterase, PDE1 hydrolyzes the 3' bond of 3'-5'-cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Here, we review evidence for this family of enzymes as drug targets for development of therapies aimed to address disorders of the central nervous system (CNS) and of ...