2018年7月24日 · In this study, we aimed to identify the specific cAMP signaling pathway modulated by PDE1C and determine the mechanism by which Ca 2+ /calmodulin-stimulated PDE1C is activated. To study cardiomyocyte death/apoptosis, we used both isolated mouse adult cardiomyocytes in vitro and doxorubicin-induced cardiotoxicity in vivo.

2024年12月25日 · PDE1C (Phosphodiesterase 1C) is a Protein Coding gene. Diseases associated with PDE1C include Deafness, Autosomal Dominant 74 and Rare Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Calmodulin induced events and Activation of cAMP-Dependent PKA.

We have characterized a novel multi-protein complex comprised of A 2 R, PDE1C, and TRPC3, in which PDE1C is activated by TRPC3-derived Ca 2+, thereby antagonizing A 2 R-cAMP signaling and promoting cardiomyocyte death/apoptosis. Targeting these molecules individually or in combination may represent a compelling therapeutic strategy for ...

2015年3月3日 · PDE1C Modulates a tmAC-cAMP-PKA Signaling Critical for Regulating PDGFRβ Protein Level. PDE1C is able to hydrolyze both cAMP and cGMP with high affinity in vitro 33. The most common cAMP and cGMP effector molecules include cAMP dependent protein kinase (PKA), exchange protein activated by cAMP (Epac), and cGMP-dependent protein kinase (PKG).

Yishuai Zhang等研究人员既往发现通过环核苷酸磷酸二酯酶1C(PDE1C)激活cAMP水解可促进心肌细胞死亡/凋亡，但其分子机制尚不清楚。 在本研究中，Yishuai Zhang等人尝试明确受PDE1C调控的特定cAMP信号通路，同时探究Ca2+/钙调蛋白激活PDE1C的机制。

Because inhibiting or silencing Ca 2+-insensitive PDEs had no such effects, these data identify PDE1C-mediated hydrolysis of cAMP as a novel and important link between SOCE and its activation of ADCY8. Functionally, we showed that PDE1C regulated the formation of leading-edge protrusions in HASMCs, a critical early event in cell migration.

2023年2月25日 · 内质网应激激活pde1c通过camp介导h9c2心肌细胞同型半胱氨酸诱导的肥大。 内质网应激抑制剂TUDCA和PDE1抑制剂Lu AF58027均能抑制同型半胱氨酸诱导的细胞增大，恢复cAMP水平。

2015年3月27日 · In cultured SMCs, PDE1C deficiency or PDE1 inhibition attenuated SMC proliferation and migration. Mechanistic studies revealed that PDE1C plays a critical role in regulating the stability of growth factor receptors, such as PDGF receptor β (PDGFRβ) known to be important in pathological vascular remodeling.

cAMP和cGMP作为神经递质、激素、光和气味等物质的第二信使，广泛作用于细胞内靶器官，如： 激酶 、离子通道及各种PDEs。 当外来信号经 跨膜传递 并引起一系列生理反应使核苷酸 环化酶 激活后(如图1所示)，cAMP和cGMP产生，PDEs家族的使命便是使之水解失活为5-单 ...

2015年1月21日 · PDE1C upregulation antagonizes the tmAC–cAMP–PKA signaling and thus suppresses PDGFRβ degradation, which facilitates SMC phenotype modulation and accelerates SMC growth/migration. PKA-dependent phosphorylation of LRP1 might be important in PDE1C-cAMP regulation of PDGFRβ protein degradation.