Dominant negative Ras attenuates pathological ventricular remodeling in ...
2015年11月1日 · We examined the possible anti-hypertrophic effect of Ras inhibition in vitro using rat neonatal cardiomyocytes (NRCM) and in vivo in the setting of pressure-overload left …
PFKP inhibition protects against pathological cardiac hypertrophy …
2025年1月1日 · In this study, we explored the role of PFKP in cardiac hypertrophic growth and HF. The expression level of PFKP was elevated both in pathological cardiac remodeling …
去氧肾上腺素 (Phenylephrine, PE) 是人工合成的拟肾上腺素类药物,与高血压、心肌肥大、心力衰竭的发生密切相关,能够直接作用于心肌细胞诱导肥大的发生 (Prasad et al., 2007)。 本研究拟 …
Small molecule QF84139 ameliorates cardiac hypertrophy via …
2021年5月9日 · In neonatal rat cardiomyocytes (NRCMs), pretreatment with QF84139 (1–10 μM) concentration-dependently inhibited phenylephrine-induced hypertrophic responses …
心肌细胞肥大体外模型的构建 - 知乎 - 知乎专栏
Angiotensin II human (Angiotensin II) acetate 是一种血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽。 Angiotensin II human acetate 在调节人类血压中起着核心作用，主要通过血管 …
心肌细胞特异性 RIP2 过表达加剧了病理重塑并导致自发性心脏肥 …
本研究进一步证实了rip2在nrcm中的过度表达可以加剧pe诱导的nrcm肥大，并且通过特异性sirna沉默tak1可以完全挽救rip2过度表达介导的心肌细胞肥大。 此外，该研究表明 RIP2 可以与 …
Genistein attenuates pathological cardiac hypertrophy in vivo …
Genistein attenuated pressure overload-induced cardiac hypertrophy in vivo and PE induced NRCM hypertrophy in vitro. The underlying mechanisms of genistein activity may be …
Modulation of hypertrophic remodeling of NCRM by Ras mutants …
NRCM hypertrophy is associated with an increase in protein synthesis [30], we assessed the effect of Ras mutants on Leucine incorporation (Fig.1C). As expected, Angiotensin-II (AT-II) …
Circulation（IF 29.69）| 心血管顶刊！蛋白组+磷酸化组联合
2022年5月11日 · 为了确定mydgf激活的信号受体，研究人员对有无mydgf存在的情况下et1刺激的心肌细胞（nrcm）进行蛋白组和磷酸化蛋白质组分析，pca分析显示不同处理组间蛋白磷酸化 …
Orai1 and Stim1 regulate normal and hypertrophic growth in ...
Both Orai1- and Stim1-KD completely abrogated phenylephrine (PE) mediated hypertrophic NRCM growth and enhanced natriuretic factor expression by inhibiting G(q)-protein conveyed …