4'-Fluorocannabidiol (also known as PECS-101 and 4'-F-CBD, and formerly as HUF-101 and HU-474 [1]) is a fluorinated cannabidiol derivative that has more potent anxiolytic, antidepressant, …

Among these derivatives, 4′-fluoro-CBD (now called PECS-101, formerly called HU-474 and HUF-101) shares many of the pharmacological effects of CBD, including reduced anxiety-like …

Our previous studies found that a fluorinated CBD analog, PECS-101 (former HUF-101), induces antinociceptive effects at lower doses than CBD in acute pain models. Part of these effects …

2024年6月8日 · PECS-101 is a semi-synthetic variant of CBD with a fluorine substitution at the 4′ position of the benzene ring component. Notably, PECS-101 exhibits more potent anxiolytic, …

2024年9月9日 · 4’-Fluoro-cannabidiol (4’-F-CBD), also referred to as HUF-101 and PECS-101 in the literature, is a recently synthesised CBD derivative [16, 17]. 4’-F-CBD is reported to exhibit...

This antiepileptic drug provides pain relief with limited efficacy and side effects. To study the antinociceptive potential of cannabidiol (CBD) and its fluorinated analog PECS-101 (former …

2024年6月8日 · Our results suggest that CBD and PECS-101 may benefit trigeminal neuralgia without motor coordination impairments. PECS-101 is more potent against the …

Here, we investigated the efficacy of PECS-101 (former HUF-101), a CBD fluorinated analog, on PTX-induced neuropathic pain in mice. PECS-101, administered after the end of treatment …

PECS-101 attenuates the increase in gene expression of proinflammatory cytokines and Aifi1 and prevents the reduction in the density of IENFs caused by PTX. After 6 h, 3, 5, and 7 days of …

2024年3月19日 · Our results suggest that CBD and PECS-101 may benefit trigeminal neuralgia without motor coordination impairments. PECS-101 is more potent against the …